Impaired Urine Dilution Capability in HIV Stable Patients

Table 1

Comparison of serum levels of solutes between HIV tenofovir group (T) and HIV nontenofovir group (nT) at baseline (B) and at maximum dilution (D) (Chaimowitz’ test): serum values—median and range.

	HIV tenofovir; baseline	HIV tenofovir; dilution	P value	HIV nontenofovir; baseline	HIV nontenofovir; dilution	P value	P value; T (B) versus nT (B); T (D) versus nT (D)
Serum urea (mg/dL)	32.5 (14–53)	26 (14–44)	0.01	36 (15–57)	33 (12–50)	0.003	NS
Serum creatinine (mg/dL)	0.82 (0.65–1.2)	0.81 (0.65–1.1)	NS	0.85 (0.58–1.07)	0.84 (0.52–1.0)	NS	NS
Serum glucose (mg/dL)	84 (68–99)	106.5 (75–145)	0.01	81 (69–105)	156 (60–220)	NS	NS
Serum uric acid (mg/dL)	4.8 (3.9–7)	4.2 (3.9–5.8)	NS	4.9 (3.1–5.4)	4.2 (2.8–6.6)	NS	NS
Serum calcium (mg/dL)	9.1 (8.1–10)	8.1 (7.7–8.8)	0.01	9.05 (8.8–10.4)	8.5 (7.8–8.7)	0.01	NS
Serum sodium (mmol/L)	137.5 (136–141)	134 (131–137)	0.009	136 (135–143)	133 (129–140)	0.01	NS
Serum potassium (mmol/L)	3.95 (3.7–5.2)	3.7 (2.7–5.0)	NS	4 (3.6–5.6)	3.6 (2.9–4.3)	0.005	NS
Serum phosphate (mmol/L)	4.1 (2.3–4.8)	2.9 (2.1–3.9)	NS	3.45 (3.2–4.3)	2.85 (2.1–3.2)	0.01	NS
Serum magnesium (mmol/L)	2.25 (2.0–2.4)	2.0 (1.8–2.2)	0.02	2.05 (1.9–2.2)	1.8 (1.5–2.0)	0.01	0.03
Serum chloride (mmol/L)	104 (96–107)	104.5 (96–108)	NS	103 (100–107)	105 (99–107)	NS	NS