Research Article
Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome
Table 3
Comparison of patient and control genotype distribution. OR, odds ratio. CI, confidence interval.
values lower than 0.05 are marked with
.
| | Gene | SNP | Genotype | Patients (%) | Controls (%) | OR (95% CI) | |
| | | | | | | | | | Angptl4 | rs1044250 (c.797C>T) | CC | 35 (35) | 30 (36) | Reference | | | CT | 46 (46) | 39 (46) | 1.01 (0.53−1.93) | 0.974 | | TT | 19 (19) | 15 (18) | 1.09 (0.47−2.53) | 0.847 | | C | 116 (58) | 99 (58.9) | Reference | | | T | 84 (42) | 69 (41.1) | 1.04 (0.69−1.58) | 0.857 |
| | | | | | | | | | GPC5 | rs16946160 (c.325+1026376G>A) | GG | 88 (88) | 86 (85) | Reference | | | GA | 12 (12) | 14 (14) | 0.84 (0.36−1.92) | 0.674 | | AA | 0 (0) | 1 (1) | (0−5.75) | 0.236 | | G | 188 (94) | 186 (92.1) | Reference | | | A | 12 (6) | 16 (7.9) | 0.74 (0.34−1.60) | 0.449 |
| | | | | | | | | | IL13 | rs848 (c.526C>A) | CC | 31 (31) | 45 (45) | Reference | | | CA | 53 (53) | 38 (38) | 2.03 (1.10−3.79) | | | AA | 16 (16) | 18 (18) | 1.29 (0.57−2.92) | 0.540 | | C | 115 (57.5) | 126 (63) | Reference | | | A | 85 (42.5) | 74 (37) | 1.26 (0.84−1.89) | 0.261 |
| | | | | | | | | | MIF | rs755622 (c.-270G>C) | GG | 61 (61) | 63 (62) | Reference | | | GC | 34 (34) | 29 (29) | 1.21 (0.66−2.23) | 0.537 | | CC | 5 (5) | 9 (9) | 0.57 (0.17−1.76) | 0.335 | | G | 156 (78) | 155 (76.7) | Reference | | | C | 44 (22) | 47 (23.3) | 0.93 (0.58−1.49) | 0.761 |
| | | | | | | | | | nNOS | rs2662826 (c.276C>T) | CC | 49 (49) | 52 (53) | Reference | | | CT | 42 (42) | 35 (35) | 1.27 (0.70−2.32) | 0.425 | | TT | 9 (9) | 12 (12) | 0.80 (0.30−2.05) | 0.636 | | C | 140 (70) | 139 (70.2) | Reference | | | T | 60 (30) | 59 (29.8) | 1.01 (0.66−1.55) | 0.965 |
| | | | | | | | | | MDR1 | rs1128503 (c.1236C>T) | CC | 22 (22) | 23 (23) | Reference | | | CT | 53 (53) | 45 (46) | 1.60 (0.82−3.19) | 0.169 | | TT | 25 (25) | 30 (31) | 1.48 (0.68−3.29) | 0.328 | | C | 97 (48.5) | 91 (46.4) | Reference | | | T |
103 (51.5) | 105 (53.6) | 0.92 (0.62−1.37) | 0.680 | | | | | | | | | rs2032582 (c.2677G>T/A) | GG | 17 (17) | 24 (24) | Reference | | | GT | 49 (49) | 45 (45) | 1.54 (0.74−3.26) | 0.253 | | TT | 26 (26) | 24 (24) | 1.53 (0.67−3.55) | 0.316 | | TA | 3 (3) | 2 (2) | 2.12 (0.32−17.42) | 0.432 | | GA | 5 (5) | 3 (3) | 2.35 (0.51−12.75) | 0.274 | | G | 88 (44) | 96 (49) | Reference | | | T | 104 (52) | 95 (48.5) | 1.19 (0.80−1.79) | 0.386 | | A | 8 (4) | 5 (2.6) | 1.75 (0.56−5.96) | 0.338 | | | | | | | | | rs1045642 (c.3435C>T) | CC | 13 (13) | 10 (10) | Reference | | | CT | 49 (49) | 53(54) | 0.711 (0.28−1.76) | 0.462 | | TT | 38 (38) | 35 (36) | 0.84 (0.32−2.14) | 0.708 | | C | 75 (37.5) | 73 (37.2) | Reference | | | T | 125 (62.5) | 123 (62.8) | 0.99 (0.66−1.49) | 0.958 |
| | | | | | | | | | GLCCI1 | rs37972 (c.-1473T>C) | CC | 35 (35) | 25 (26) | Reference | | | CT | 49 (49) | 56 (58) | 0.63 (0.38−1.18) | 0.149 | | TT | 16 (16) | 16 (16) | 0.71 (0.30−2.70) | 0.444 | | C | 119 (59) | 106 (54.6) | Reference | | | T | 81 (41) | 88 (45.4) | 0.82 (0.55−1.22) | 0.330 | | | | | | | | | rs37973 (c.-1106G>A) | AA | 33 (33) | 24 (27) | Reference | | | GA | 50 (50) | 52 (58) | 0.70 (0.36−1.34) | 0.282 | | GG | 17 (17) | 14 (16) | 0.88 (0.37−2.15) | 0.782 | | A | 116 (58) | 100 (55.6) | | | | G | 84 (42) | 80 (44.4) | 0.91 (0.60−1.36) | 0.631 |
| | | | | | | | | | NR3C1 | rs41423247 (c.1184+646C>G) | GG | 32 (32) | 37 (41) | Reference | | | GC | 47 (47) | 37 (41) | 1.47 (0.78−2.80) | 0.238 | | CC | 21 (21) | 16 (18) | 1.52 (0.68−3.43) | 0.308 | | G | 111 (55.5) | 111 (61.7) | Reference | | | C | 89 (44.5) | 69 (38.3) | 1.29 (0.86−1.95) | 0.223 |
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