International Journal of Nephrology / 2016 / Article / Tab 4 / Research Article
Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome Table 4 Comparison of genotype and allele frequencies of functional kidney gene variants and selected clinical features.
values lower than 0.05 are marked with
.
Gene SNP Genotype Relapses Frequent relapser (%) Age of onset (%) Response to steroids Treatment <5 >5 No Yes <3 >3 Normal Slow/NR Only GC IS Angptl4 rs1044250 (c.797C>T) CC 20 (38) 11 (44) 0.9426 14 (34) 18 (44) 0.4133 8 (50) 24 (37) 0.3311 25 (37) 6 (46) 0.8494 12 (29) 20 (51) 0.0679 CT 25 (48) 11 (44) 19 (46) 18 (44) 6 (38) 31 (48) 32 (48) 5 (38) 21 (50) 16 (41) TT 7 (13) 3 (12) 8 (20) 4 (10) 2 (13) 10 (15) 10 (15) 2 (15) 9 (21) 3 (8) C 65 (62.5) 33 (66) 0.7230 47 (57) 54 (68) 0.1977 22 (69) 79 (61) 0.5416 82 (61) 17 (65) 0.8094 45 (54) 56 (72) T 39 (37.5) 17 (34) 35 (43) 26 (33) 10 (31) 51 (39) 52 (39) 9 (35) 39 (46) 22 (28) GPC5 rs16946160 (c.325+1026376G>A) GG 47 (90) 20 (80) 0.2789 37 (90) 33 (83) 0.3493 11 (69) 59 (91) 58 (87) 11 (85) 1.000 38 (90) 32 (82) 0.3389 GA 5 (10) 5 (20) 4 (10) 7 (18) 5 (31) 6 (9) 9 (13) 2 (15) 4 (10) 7 (18) AA 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) G 99 (95) 45 (90) 0.2951 78 (95) 73 (91) 0.3663 27 (84) 124 (95) 125 (93) 24 (92) 0.6322 80 (95) 71 (91) 0.3567 A 5 (5) 5 (10) 4 (5) 7 (9) 5 (16) 6 (5) 9 (7) 2 (8) 4 (5) 7 (9) IL13 rs848 (c. CC 18 (35) 8 (32) 0.8456 10 (24) 16 (40) 0.3114 7 (44) 19 (29) 0.6420 24 (36) 2 (15) 0.3703 15 (36) 11 (28) 0.7568 CA 25 (48) 14 (56) 24 (59) 19 (48) 7 (44) 35 (54) 33 (49) 9 (69) 21 (50) 21 (54) AA 9 (17) 3 (12) 7 (17) 5 (13) 2 (13) 11 (17) 10 (15) 2 (15) 6 (14) 7 (18) C 61 (59) 30 (60) 1.000 44 (54) 51 (64) 0.2056 21 (66) 73 (56) 0.4246 81 (60) 13 (50) 1.000 51 (61) 43 (55) 0.5253 A 43 (41) 20 (40) 38 (46) 29 (36) 11 (34) 57 (44) 53 (40) 13 (50) 33 (39) 35 (45) MIF rs755622 (c.-270G>C) GG 31 (60) 16 (64) 1.000 26 (63) 24 (60) 0.9284 9 (56) 40 (62) 0.0634 40 (60) 8 (62) 1.000 25 (60) 24 (62) 0.7481 GC 18 (35) 8 (32) 13 (32) 14 (35) 7 (44) 21 (32) 23 (34) 5 (38) 14 (33) 14 (36) CC 3 (6) 1 (4) 2 (5) 2 (5) 0 (0) 4 (6) 4 (6) 0 (0) 3 (7) 1 (3) G 80 (77) 40 (80) 0.8359 65 (79) 62 (78) 0.8497 25 (78) 101 (78) 1.000 103 (77) 21 (81) 1.000 64 (76) 62 (79) 0.7063 C 24 (23) 10 (20) 17 (21) 18 (23) 7 (22) 29 (22) 31 (23) 5 (19) 20 (24) 16 (21) nNOS rs2662826 (c. CC 24 (46) 10 (4) 0.7393 19 (46) 17 (43) 0.2027 5 (31) 31 (48) 0.4080 29 (43) 7 (54) 0.6178 19 (45) 17 (44) 0.5406 CT 23 (44) 11 (44) 20 (49) 16 (40 8 (50) 28 (43) 31 (46) 4 (31) 20 (48) 16 (41) TT 5 (10) 4 (16) 2 (5) 7 (18) 3 (19) 6 (9) 7 (10) 2 (15) 3 (7) 6 (15) C 71 (68) 31 (62) 0.4702 58 (71) 50 (63) 0.4075 18 (56) 90 (69) 0.2089 89 (66) 18 (69) 0.458 58 (69) 50 (64) 0.5103 T 33 (32) 19 (38) 24 (29) 30 (38) 14 (44) 40 (31) 45 (34) 8 (31) 26 (31) 28 (36)
