International Journal of Nephrology / 2016 / Article / Tab 5 / Research Article
Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome Table 5 Comparison of genotype and allele frequencies of glucocorticoid metabolism gene variants and selected clinical features. GC, glucocorticoid medication. NR, no response. IS, immunosuppressive drugs.
values lower than 0.05 are marked with
.
Gene SNP Genotype Relapses Frequent relapser (%) Age of onset (%) Response to GC Treatment <5 >5 No Yes <3 >3 Normal Slow/NR Only GCs IS MDR1 rs1128503 (c.1236C>T) CC 12 (23) 4 (16) 0.2330 9 (22) 8 (20) 0.4526 1 (6) 16 (25) 0.2863 14 (21) 3 (23) 1.000 12 (29) 5 (17) CT 29 (56) 11 (44) 23 (56) 18 (45) 10 (63) 31 (48) 34 (51) 6 (46) 24 (57) 7 (24) TT 11 (21) 10 (40) 9 (22) 14 (35) 5 (31) 18 (28) 19 (28) 4 (31) 6 (14) 17 (59) C 53 (51) 19 (38) 0.1678 41 (50) 34 (43) 0.3496 12 (38) 63 (48) 0.3240 62 (46) 12 (46) 0.0566 48 (57) 17 (29) T 51 (49) 31 (62) 41 (50) 46 (58) 20 (63) 67 (52) 72 (54) 14 (54) 36 (43) 41 (71) rs2032582 (c.2677G>T/A) GG 9 (17) 4 (16) 0.5655 6 (15) 7 (18.5) 0.3793 1 (6) 12 (18) 0.3311 12 (18) 1 (8) 0.4136 10 (24) 3 (8) GT 25 (48) 11 (44) 22 (54) 17 (43.5) 7 (44) 32 (49) 32 (48) 6 (46) 22 (53) 17 (44) TT 13 (25) 10 (40) 9 (22) 15 (38.5) 7 (44) 17 (26) 20 (30) 4 (31) 6 (14) 18 (46) TA 2 (4) 0 (0) 2 (5) 0 (0) 1 (6) 1 (2) 1 (1) 1 (8) 2 (5) 0 (0) GA 3 (6) 0 (0) 2 (5) 1 (3.5) 0 3 (5) 2 (3) 1 (8) 2 (5) 1 (3) G 46 (44) 19 (38) 0.1985 36 (44) 32 (40) 0.3448 9 (28) 59 (45) 0.1642 58 (43) 9 (35) 0.0529 44 (52) 24 (31) T 53 (51) 31 (62) 42 (51) 47 (59) 22 (69) 67 (52) 73 (54) 15 (58) 36 (43) 53 (68) A 5 (6) 0 (0) 4 (5) 1 (1) 1 (3) 4 (3) 3 (3) 2 (8) 4 (5) 1 (1) rs1045642 (c.3435C>T) CC 9 (17) 4 (16) 1.000 8 (20) 5 (12) 0.4179 0 (0) 13 (20) 12 (18) 1 (8) 0.8447 10 (24) 3 (8) CT 23 (44) 11 (44) 19 (46) 16 (39) 11 (69) 24 (37) 28 (42) 6 (46) 20 (48) 15 (38) TT 20 (38) 10 (40) 14 (34) 19 (46) 5 (31) 28 (43) 27 (40) 6 (46) 12 (29) 21 (54) C 41 (39) 19 (38) 1.000 35 (43) 26 (33) 1.1977 11 (34) 50 (38) 0.8389 52 (39) 8 (31) 40 (48) 21 (27) T 63 (61) 31 (62) 47 (57) 54 (68) 21 (66) 80 (62) 82 (61) 18 (69) 44 (52) 57 (73) GLCCI1 rs37972 (c.-1473T>C) CC 16 (31) 11 (44) 0.4931 13 (32) 15 (38) 0.8291 8 (50) 20 (31) 0.2289 24 (36) 4 (31) 1.000 11 (26) 17 (44) 0.2726 CT 26 (50) 11 (44) 21 (51) 20 (50) 5 (31) 35 (54) 33 (49) 7 (54) 23 (55) 17 (44) TT 10 (19) 3 (12) 7 (17) 5 (13) 3 (19) 10 (15) 10 (15) 2 (15) 8 (19) 5 (13) C 58 (56) 33 (66) 0.2938 47 (57) 50 (63) 0.525 21 (66) 75 (58) 0.5473 81 (60) 15 (58) 1.000 45 (54) 51 (65) 0.1506 T 46 (44) 17 (34) 35 (43) 30 (38) 11 (34) 55 (42) 53 (40) 11 (42) 39 (46) 27 (35) rs37973 (c.-1106G>A) AA 14 (27) 12 (48) 0.1197 12 (29) 15 (38) 0.6024 8 (50) 19 (29) 0.1861 22 (33) 5 (38) 0.8423 9 (21) 18 846) 0.0623 GA 26 (50) 11 (44) 21 (51) 20 (50) 5 (31) 35 (54) 33 (49) 7 (54) 24(57) 16 (41) GG 12 (23) 2 (8) 8 (20) 5 (13 3 (19) 11 (17) 12 (18) 1 (8) 9 (21) 5 (13) A 54 (52) 35 (70) 45 (55) 50 (63) 0.3427 21 (66) 73 (56) 0.4246 77 (57) 17 (65) 0.6321 42 (50) 52 (67) G 50 (48) 15 (30) 37 (45) 30 (38) 11 (34) 57 (44) 57 (43) 9 (35) 42 (50) 26 (33) NR3C1 rs41423247 (c.1184+646C>G) GG 20 (38) 5 (20) 14 (34) 11 (28) 5 (31) 21 (32) 0.5928 23 (34) 2 (15) 0.2363 16 (38) 10 (26) 0.0655 GC 17 (33) 17 (68) 14 (34) 24 (60) 6 (38) 31 (48) 31 (46) 6 (46) 14 (33) 23 (59) CC 15 (29) 3 (12) 13 (32) 5 (13) 5 (31) 13 (20) 13 (19) 5 (38) 12 (29) 6 (15) G 57 (55) 27 (54) 1.000 42 (51) 46 (58) 0.4352 16 (50) 73 (56) 0.5571 77 (57) 10 (38) 0.3479 46 (55) 43 (55) 1.000 C 47 (45) 23 (46) 40 (49) 34 (43) 16 (50) 57 (44) 57 (43) 16 (62) 38 (45) 35 (45)
