Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome

Table 7

Comparison between the found associations of the analyzed SNPs in this study and in previous studies.

Gene	Found association	Current study	Referenced study
GPC5	rs16946160 (c.325+1026376G>A)
	Association of AA genotype with NS	No	Yes [7]
	Association of A allele with disease onset	Yes
	A allele frequency	0,168	0,08 [7]
IL13	rs848 (c.526C>A)
	Association of genotype distribution with long term outcome	No	Yes [4]
MIF	rs755622 (c.-270G>C)
	Association of C allele and/or GC genotype with NS	No	Yes [5], yes [6], no [22]
	Association of CC genotype with GC resistance	No	Yes [5], yes [6], no [22]
nNOS	rs2662826 (c.276C>T)
	Association of TT genotype with NS	No	Yes [8]
	Association of TT genotype with GC responsiveness	No	No [8]
MDR1	rs1128503 (c.1236C>T)
	Association of T allele and/or TT genotypes with IS medication need	Yes
	rs2032582 (c.2677G>T/A)
	Association of genotype distribution with NS	No	No [9], yes [11], yes [12], no [22]
	Association of CC genotype with age of onset	No	No [9], no [11], yes [12], no [22]
	Association of T allele and/or TT genotype with GC responsiveness	Yes
	Association of T allele and/or TT genotypes with IS medication need	Yes
	rs1045642 (c.3435C>T)
	Association of T allele and/or TT genotype with NS	No	Yes [9], yes [11], yes [12], no [22]
	Allele frequencies of controls (C/T, %)	37.2/62.8	45,2/54,8 [9], 66.4/33.6 [11], 58.5/41.5 [12], 42.0/58.0 [22], 42.4/57.6 [30]
	Association of CC genotype with age of onset	Yes	No [9], no [11], yes [12], no [22]
	Association of T allele and/or TT genotypes with IS medication need	Yes
	Haplo type
	Association with GC responsiveness	No	Yes [9], yes [12], yes [22], no [30]
	Frequency of TGC haplotype (case/control, %)	6.5.2010	1.1 [9], 8.3/6.5 [11], 21,7/18.6 [12], 21.2/18 [22], 1.1/2.3 [30]
GLCCI1	rs37972 (c.-1473T>C)
	Association of genotype distribution with GC responsiveness	No	No [16]
	rs37973 (c.-1106G>A)
	Association of genotype distribution with GC responsiveness	No	No [16]
	Association of A allele with patients with more than five relapses	Yes
	Association of A allele with IS medication need	Yes

Only control.