Murine Nephrotoxic Nephritis as a Model of Chronic Kidney Disease

Table 1

Histopathological lesions by mouse strains. The tubular casts were visualised as solidification of protein in the lumen of the kidney tubules. The metaplasia was visualised as a change from flattened parietal epithelium to cuboidal epithelium lining the glomerulus. The segmental glomerulosclerosis was visualised as glomeruli that showed scarring of small sections of the glomeruli, while global glomerulosclerosis was visualised as totally scarred glomeruli.

Pathologic changes; NTN mice	CD1 day 7	%	B6 day 7	%	CD1 day 21	%	B6 day 21	%	CD1 day 42	%	B6 day 42	%
Tubular casts (cortex)
Present (yes/no)	9	100	6	100	9	90	6	100	7	86	6	86
Metaplasia
	47	26	35	29	54	27	32	27	38	24	33	24
Glomerulosclerosis (segmental)
	39	22	24	20	44	22	25	21	35	22	20	14
Glomerulosclerosis (global)
	4	2	2	2	22	11	8	7	20	13	18	13