Renin-Angiotensin System Induced Secondary Hypertension: The Alteration of Kidney Function and Structure

Table 1

RAS receptor distribution change in response to hypertension. AT₁R distribution change related to time after 2K1C or 2K1W in hypertensive rat models.

Major RAS receptors		Hypertension
AT1 receptor		Aorta AT1R expression; Vascular and glomerular AT1R downregulation; Proximal tubular receptors upregulation or not significantly altered
AT1 receptor alteration after 2K1C or 2K1W in hypertensive rat models		Time after clipping
	1 week	AT1R mRNA in the clipped, wrapped, and contralateral kidneys
	10 days	AT1AR protein in clipped and unclipped kidneys
	2 weeks	Glomerular AT1R
	10 weeks	AT1R mRNA levels in clipped and unclipped kidneys
	16 weeks	Vascular AT1R
AT2 receptor		Aorta AT2R expression unchanged; Sodium depletion & SHR AT2R expression; AT2R downregulation only in clipped and wrapped kidneys, in 2K1C and 2K1W
Mas receptor		Carotid MasR protein expression in 2K1C rats; MasR in proximal tubules of clipped kidney in male rats; MasR in clipped and unclipped kidney of female rats