Immunohistochemical Expression of FOXP3+ Regulatory T Cells in Proteinuric Primary Glomerulopathies

Figure 2

FOXP3+ Tregs detection inside inflammatory cell infiltrates was frequent. They were observed in the interstitial tissue in 64% of patients with IgAN, 77% of patients with FSGS, and 76% of patients with MGN. (a) Comparative diagram of FOXP3+/CD4+ ratio in the interstitial tissue ( value >0.05 for all comparisons). No statistical difference was found between the three glomerulopathies in FOXP3+ Tregs over the CD4+ ratio. (b) Comparative diagram of absolute FOXP3+ Tregs count in the interstitial tissue (per mm²; value >0.05 for all comparisons). No statistical difference was found between the three glomerulopathies in absolute FOXP3+ Tregs count. FSGS: focal segmental glomerulosclerosis, IgAN: IgA nephropathy, MGN: membranous glomerulopathy, and Tregs: regulatory T cells.

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