Immunohistochemical Expression of FOXP3+ Regulatory T Cells in Proteinuric Primary Glomerulopathies
Table 2
Light microscopy histological lesions.
Total (N = 71)
IgAN (N = 28)
FSGS (N = 22)
MGN (N = 21)
value
Total glomeruli
20 ± 11
21 ± 10
21 ± 13
18 ± 8
ns
Patients with segmental sclerosis (%)
66
61
100
29
<0.001
Percentage of segmentally sclerosed glomeruli over total glomeruli
10 ± 10
10 ± 9a,b
16 ± 9a,c
3 ± 5b,c
a: 0.012 b: 0.003 c: <0.001
Patients with global glomerulosclerosis (%)
82
89
86
67
ns
Percentage of globally sclerosed glomeruli over total glomeruli
24 ± 21
26 ± 21
33 ± 24α
13 ± 13α
α: <0.001
Interstitial fibrosis-tubular atrophy (%)
<25
52
50
41
67
ns
≥25–<50
38
43
36
33
ns
≥50
10
7
23
0
ns
Interstitial inflammation (%)
Absent
30
25
23
43
ns
Sparse
27
25
32
24
ns
Dense
44
50
45
33
ns
Patients with interstitial inflammation inside fibrotic areas (%)
61
61
73
48
ns
Patients with arteriolar hyalinosis (%)
61
75
55
48
ns
Patients with crescents (%)
8
21
0
0
0.004
Percentage of glomeruli with crescents over total glomeruli
1 ± 4
3 ± 7
0
0
0.028
Note. Data are presented as mean value ± standard deviation or as percentage. FSGS: focal segmental glomerulosclerosis, IgAN: IgA nephropathy, MGN: membranous glomerulopathy, and ns: not significant.
