Immunohistochemical Expression of FOXP3+ Regulatory T Cells in Proteinuric Primary Glomerulopathies
Table 3
FOXP3+/CD4+ and FOXP3+/CD3+ ratios in the interstitial tissue and periglomerular space and qualitative assessment of FOXP3+ Tregs’ presence inside glomeruli and between tubular cells.
Total
IgAN
FSGS
MGN
value
FOXP3+/CD4+ ratio in interstitial tissue
0.185 ± 0.200
0.146 ± 0.158
0.202 ± 0.192
0.213 ± 0.250
ns
FOXP3+/CD3+ ratio in interstitial tissue
0.100 ± 0.129
0.114 ± 0.136
0.081 ± 0.138
0.103 ± 0.111
ns
FOXP3+/CD4+ ratio in periglomerular space
0.099 ± 0.155
0.130 ± 0.188
0.072 ± 0.106
0.089 ± 0.155
ns
FOXP3+/CD3+ ratio in periglomerular space
0.055 ± 0.104
0.046 ± 0.082
0.054 ± 0.106
0.066 ± 0.128
ns
Patients with FOXP3+ Tregs’ presence inside glomeruli (%)
6
4
5
10
ns
Patients with FOXP3+ Tregs’ presence between tubular cells (%)
25
29
27
19
ns
Note. Data are presented as mean value ± standard deviation or as percentage. FSGS: focal segmental glomerulosclerosis, IgAN: IgA nephropathy, MGN: membranous glomerulopathy, ns: not significant, and Tregs: regulatory T cells.
