Intravenous Administration of Cisplatin with Magnesium Sulfate Supplement May Prevent Kidney Toxicity in Rats: The Role of Gender and Magnesium Sulfate Dose

Figure 1

(a) The serum levels of blood urea nitrogen (BUN), creatinine (Cr), and magnesium (Mg), (b) clearance of Cr (ClCr), urine flow (UF), and urinary load of sodium, (c) kidney tissue damage score (KTDS), percentage decrease of body weight (BW), and normalized kidney weight (KW), and (d) the serum levels of malondialdehyde (MDA), nitrite, and lactate dehydrogenase (LDH) in 12 groups of experiments including saline, saline + KCl + Mg3, CP, CP + KCl + MgSO₄, CP + KCl + Mg1, CP + KCL + Mg3, and CP + KCl + Mg10 (see Table 1 for groups’ details). ^∗, #, and & indicated significant differences from saline, saline + KCl + Mg3, and CP groups, respectively.

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