Intravenous Administration of Cisplatin with Magnesium Sulfate Supplement May Prevent Kidney Toxicity in Rats: The Role of Gender and Magnesium Sulfate Dose

Table 1

The summary of study groups. The duration time of fluid administration before, during, and after CP therapy was 45, 30, and 45 minutes, respectively, using a microinfusion pump.

Group number	Gender	Group name	Treatment
			Before CP therapy	During CP therapy	After CP therapy
1, 7	M, F	Saline	2 ml of saline	1.5 ml of saline alone	2 ml of saline
2, 8	M, F	Saline + KCl + Mg3	2 ml of fluid containing saline, 0.015 meq/ml of KCl, and 3 mg/ml of MgSO4	1.5 ml of saline alone	2 ml of fluid containing saline, 0.015 meq/ml of KCl, and 3 mg/ml of MgSO4
3, 9	M, F	CP	—	1.5 ml of saline containing 7.5 mg/kg of CP	—
4, 10	M, F	CP + KCl + Mg1	2 ml of fluid containing saline, 0.015 meq/ml of KCl, and 1 mg/ml of MgSO4	1.5 ml of saline containing 7.5 mg/kg of CP	2 ml of fluid containing saline, 0.015 meq/ml of KCl, and 1 mg/ml of MgSO4
5, 11	M, F	CP + KCl + Mg3	2 ml of fluid containing saline, 0.015 meq/ml of KCl, and 3 mg/ml of MgSO4	1.5 ml of saline containing 7.5 mg/kg of CP	2 ml of fluid containing saline, 0.015 meq/ml of KCl, and 3 mg/ml of MgSO4
6, 12	M, F	CP + KCl + Mg10	2 ml of fluid containing saline, 0.015 meq/ml of KCl, and 10 mg/ml of MgSO4	1.5 ml of saline containing 7.5 mg/kg of CP	2 ml of fluid containing saline, 0.015 meq/ml of KCl, and 10 mg/ml of MgSO4

KCl: potassium chloride; MgSO₄: magnesium sulfate; M: male; F: female.