Research Article
Analysis of Various Types of Glomerulonephritis with Crescents at a Single Center
Table 1
Clinical and pathological findings according to the four classifications of rapid progressive glomerulonephritis.
| | Type II (n = 149) | Type III (n = 47) | value | | LN (40) | IgA–N (78) | IgA–VN (31) | MPA (47) |
| | Clinical findings | | | | | | | Age (years) | 39.5 (32.3–50) | 33.5 (26–42.3) | 30.5 (24.5–44) | 64 (54–70.5) | <0.0001 | | Sex (male/female) | 7/33 (M:18%) | 37/41 (M:47%) | 22/9 (M:71%) | 18/30 (M:38%) | 0.0002 | | Mean arterial pressure (mmHg) | 91 (84.3–107.2) | 92.2 (84.9–100) | 93 (81.7–98.7) | 96 (82.7–105.8) | 0.6150 | | Body mass index | 22.0 (20.5–23.6) | 21.3 (19.7–23.4) | 21.4 (19.3–24.4) | 21.6 (19.9–24.3) | 0.5850 | | Total serum protein (g/dL) | 5.8 (4.7–6.2) | 6.6 (6.1–7) | 6.5 (5.9–6.9) | 6.6 (6.2–7.2) | <0.0001 | | Serum albumin (g/dL) | 2.9 (2.2–3.5) | 3.9 (3.5–4.2) | 3.7 (3.2–4.2) | 3.2 (2.6–4) | <0.0001 | | Blood urea nitrogen (mg/dL) | 18 (13.4–23.9) | 14 (12.1–17.8) | 13.1 (11.9–17.2) | 26.7 (18.2–43.2) | <0.0001 | | Serum creatinine (mg/dL) | 0.79 (0.62–1.09) | 0.78 (0.67–1.04) | 0.78 (0.67–0.91) | 1.71 (1.03–2.76) | <0.0001 | | Estimated GFR (mL/min/1.73 m2) | 71.4 (46.3–93.1) | 75.9 (57–95.6) | 85.5 (69.5–107.8) | 25 (16.8–42.9) | <0.0001 | | Urine protein (g/g creatinine) | 1.9 (0.88–4.7) | 1.19 (0.66–2.34) | 2 (0.78–3.37) | 1.54 (0.74–2.75) | 0.0340 | | Urine red blood cell count (counts/HPF) | 20 (5–30) | 20 (10–42.5) | 30 (10–50) | 20 (10–30) | 0.2950 | | IgG (mg/dL) | 1183 (849–1685) | 1049 (850–1298) | 893.5 (737–1110) | 1338 (1047–1626) | 0.0002 | | IgA (mg/dL) | 232 (170.5–305) | 283 (221–386) | 251 (196.3–369.5) | 215 (166–281) | 0.0027 | | IgM (mg/dL) | 73.5 (48–101) | 128 (88–168) | 104.5 (84–153.3) | 89 (58–115) | <0.0001 | | CH50 (mg/dL) | 26.9 (20–36.3) | 40 (35.2–47.6) | 47.5 (44.1–53) | 51.3 (43.6–59.0) | <0.0001 | | C3 (mg/dL) | 50.1 (36–72.3) | 94.6 (83.9–108.6) | 110 (91.4–121) | 106.6 (95.8–121) | <0.0001 | | C4 (mg/dL) | 9.45 (3.9–17.2) | 22.3 (19.7–27.6) | 23.6 (20–29.9) | 26.9 (22.0–34.1) | <0.0001 | | Complications (%) | | | | | | | Diabetes mellitus | 3 (7.5) | 2 (2.6) | 4 (12.9) | 5 (10.4) | 0.0786 | | Hypertension | 10 (25) | 22 (28.2) | 8 (25.8) | 20 (41.7) | 0.0698 | | Dyslipidemia | 11 (27.5) | 20 (25.6) | 8 (25.8) | 24 (50) | 0.8289 | | Hyperuricemia | 5 (12.5) | 9 (11.5) | 1 (3.2) | 9 (18.8) | 0.2362 | | Treatment (%) | | | | | | | Antiplatelet drug | 21 (52.5) | 62 (79.5) | 24 (77.4) | 16 (33.3) | <0.0001 | | ACEI/ARB | 13 (32.5) | 47 (60.3) | 14 (45.2) | 25 (52.1) | 0.0282 | | Pathological finding | | | | | | Percentage of global
glomerulosclerosis (%) | 5.1 (0–16.3) | 11.1 (2.6–25.4) | 8.3 (0–22.2) | 27.8 (6.7–38.4) | <0.0001 | Percentage of crescents
(Cellular/fibrocellular/fibrous) (%) | 15.1 (7.7–36.7) | 16.7 (10.2–26.5) | 14.3 (9.1–18.2) | 28 (20.6–51.7) | <0.0001 | | Tubulointerstitial lesionsa (0/1/2/3) | 14/18/4/2 | 11/39/25/3 | 9/20/3/0 | 9/11/11/12 | 0.0001 | | Arteriosclerosisb (0/1/2/3) | 25/7/6/2 | 40/17/14/1 | 20/5/4/2 | 16/13/11/4 | 0.0724 | | Arteriolar sclerosisb (0/1/2/3) | 27/9/4/0 | 33/26/16/2 | 18/8/4/1 | 16/19/8/1 | 0.0283 | | Percentage of normal glomeruli (%) | 69.0 (55.5–86.0) | 64.0 (44.8–75.0) | 71.0 (60.0–83.0) | 34.5 (21.0–54.5) | <0.0001 |
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GFR, Glomerular filtration rate, HPF, high-power field; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin II receptor blocker. aTubular atrophy and interstitial fibrosis score: <5%, 0; 5 ≤ lesion <20, 1; 20 ≤ lesion < 50, 2; ≥50, 3. bArteriosclerosis and arteriolosclerosis score: none or low, 0; middle, 1; high, 2; and very high 3.
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