Analysis of Various Types of Glomerulonephritis with Crescents at a Single Center

Table 3

Univariate and multivariate analysis of factors affecting renal prognosis between type II and type III rapid progressive glomerulonephritis.

	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Type III (vs. type II)	15.08	3.08–73.9	0.0001	0.07	0.01–2.52	0.10522
Age (15 years of increase)	2.60	1.45–4.67	0.0005	0.67	0.15–2.99	0.59377
Male (vs. Female)	0.92	0.25–3.38	0.9036
MAP (10 mm Hg increase)	2.05	1.15–3.67	0.0125
BMI (3 kg/m2 increase)	1.23	0.70–2.16	0.463
eGFR (30 mL/min/1.73 m2 decrease)	17.57	2.55–121	<0.0001	8.57 E+08	–	0.00012
T-chol (30 mg/dL increase)	0.46	0.26–0.81	0.0034	0.29	0.10–0.86	0.00448
TG (30 mg/dL increase)	0.35	0.07–1.82	0.0541
U-Prot (0.5 g/g Cr increase)	1.13	0.88–1.45	0.3329
U-RBC (25 counts/HPF increase)	0.98	0.54–1.76	0.9348
ACEI/ARB use (vs. nonuse)	0.89	0.22–3.65	0.8677
Antiplatelet drugs use (vs. nonuse)	0.75	0.16–3.46	0.7168
Percentage of global glomerulosclerosis^a	1.11	1.06–1.16	<0.0001	8.99	1.40–57.9	0.00176
Percentage of crescents^b (cellular/fibrocellular/fibrous)	1.83	1.01–3.33	0.0486
Tubular atrophy and interstitial fibrosis^c	6.69	2.22–22.2	0.0001	0.83	0.19–3.55	0.80201
Percentage of normal glomeruli^d	0.22	0.08–0.58	0.0004	1.84	0.28–12.2	0.51339
Arteriosclerosis score^e	1.83	1.83–0.95	0.071
Arteriolosclerosis score^e	2.67	1.26–6.03	0.0111

HR, hazard ratio; CI, confidence interval; MAP, mean arterial pressure; BMI, body mass index; Alb, serum albumin; eGFR, estimated glomerular filtration rate; T-chol, total cholesterol; TG, triglycerides; U-Prot, total urine protein; U-RBC, urine red blood cell count; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin II receptor blocker. ^aGlobal glomerulosclerosis score: < 10%, 0; 10 ≤ lesion < 25%, 1; 25 ≤ lesion < 50%, 2; 50 ≤ lesion < 75%, 3; ≥75%, 4. ^bCrescent score: <10%, 0; 10 ≤ lesion < 25%, 1; 25 ≤ lesion < 50%, 2; 50 ≤ lesion < 75%, 3; ≥75%, 4. ^cTubular atrophy and interstitial fibrosis score: <5%, 0; 5 ≤ lesion < 20, 1; 20 ≤ lesion < 50, 2; ≥50, 3. ^dNormal glomeruli score: > 75%, 0; 50 < lesion ≤ 75, 1; 25 < lesion ≤ 50, 2; ≤ 25, 3. ^eArteriosclerosis and arteriolosclerosis score: none or low, 0; middle, 1; high, 2; and very high, 3.