Analysis of Various Types of Glomerulonephritis with Crescents at a Single Center

Table 4

Univariate and multivariate analysis of factors affecting renal prognosis microscopic polyangiitis and immunoglobulin A nephropathy.

	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
MPA (vs. IgA-N)	15.8	1.91–131	0.0009	0.35	0.01–37.9	0.65774
Age (15 years increase)	2.01	1.13–3.60	0.0129
Male (vs. Female)	0.64	0.15–2.67	0.5302
MAP (10 mm Hg increase)	2.06	1.08–3.93	0.0225
BMI (3 kg/m2 increase)	1.10	0.61–1.99	0.7415
eGFR (30 mL/min/1.73 m2 decrease)	13.0	1.88–90.5	<0.0001	4.E+0.7	–	0.04942
T-chol (30 mg/dL increase)	0.50	0.28–0.92	0.0170
TG (30 mg/dL increase)	0.50	0.11–2.33	0.2424
U-Prot (0.5 g/g Cr increase)	1.30	0.98–1.73	0.0907
U-RBC (25 counts/HPF increase)	0.89	0.47–1.70	0.7247
ACEI/ARB use (vs. nonuse)	0.88	0.19–4.13	0.8741
Antiplatelet drugs use (vs. nonuse)	1.05	0.18–6.01	0.9526
Percentage of global glomerulosclerosis^a	74.3	6.89–803	<0.0001	23.3	1.41–386	0.00127
Percentage of crescents^b (cellular/fibrocellular/fibrous)	1.96	0.98–3.89	0.0564
Tubular atrophy and interstitial fibrosis^c	10.0	2.42–41.7	0.0001	2.51	0.50–12.6	0.23657
Percentage of normal glomeruli^d	0.08	0.02–0.38	<0.0001	0.38	0.02–7.74	0.53297
Arteriosclerosis score^e	1.89	0.90–4.10	0.0903
Arteriolosclerosis score^e	2.60	1.13–6.57	0.0252

HR, hazard ratio; CI, confidence interval; MAP, mean arterial pressure; BMI, body mass index; Alb, serum albumin; eGFR, estimated glomerular filtration rate; T-chol, total cholesterol; TG, triglycerides; U-Prot, total urine protein; U-RBC, urine red blood cell count; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin II receptor blocker. ^aGlobal glomerulosclerosis score: <10%, 0; 10 ≤ lesion < 25%, 1; 25 ≤ lesion < 50%, 2; 50 ≤ lesion < 75%, 3; ≥75%, 4. ^bCrescent score: <10%, 0; 10 ≤ lesion < 25%, 1; 25 ≤ lesion < 50%, 2; 50 ≤ lesion < 75%, 3; ≥75%, 4. ^cTubular atrophy and interstitial fibrosis score: <5%, 0; 5 ≤ lesion < 20, 1; 20 ≤ lesion < 50, 2; ≥50, 3. ^dNormal glomeruli score: >75%, 0; 50 < lesion ≤ 75, 1; 25 < lesion ≤ 50, 2; ≤ 25, 3. ^eArteriosclerosis and arteriolosclerosis score: none or low, 0; middle, 1; high, 2; and very high 3.