Urinary Podocyte Excretion Predicts Urinary Protein Selectivity and Renal Prognosis

Table 4

Physiological data at the time of the renal biopsy according to the response of proteinuria.

	CR	PR	NS	P
Age (year-old)	48 ± 2	52 ± 3	58 ± 4	0.27
Sex (M1:F0)	0.44 ± 0.06	0.55 ± 0.08	0.33 ± 0.17	0.37
BH (cm)	160.4 ± 1.1	162.2 ± 1.3	158.0 ± 4.5	0.44
BW (kg)	62.5 ± 1.6	64.9 ± 2.1	57.8 ± 5.6	0.34
SBP (mmHg)	101 ± 2	104 ± 3	118 ± 8	0.07
DBP (mmHg)	75 ± 1	76 ± 1	75 ± 4	0.89
PR (/min)	73 ± 1	74 ± 2	75 ± 4	0.08
PP × PR (WHP) (mmHg/min)	1910 ± 144	2126 ± 262	3382 ± 594^+	0.014
WHP × BW (mmHg kg/min)	122060 ± 10764	136609 ± 17076	185601 ± 28861	0.07
Serum Cr (mg/dL)	1.17 ± 0.14	1.81 ± 0.28	1.63 ± 0.39	0.018
eGFR (ml/min/1.73m2)	67.3 ± 3.56	54.9 ± 5.82	43.0 ± 7.60	0.023
Serum UN (mg/dL)	22.1 ± 1.80	24.1 ± 2.10	26.1 ± 3.50	0.64
Serum UA (mg/dL)	6.6 ± 0.95	6.1 ± 0.25	6.4 ± 0.54	0.93
Serum TP (g/dL)	6.0 ± 0.16	6.3 ± 0.17	6.1 ± 0.44	0.56
Serum Alb (g/dL)	3.0 ± 0.15	3.0 ± 0.12	2.6 ± 0.20	0.56
Serum IgG (mg/dL)	1108 ± 63.5	1339 ± 126	1445 ± 392	0.14
UP (g/gCr)	3.28 ± 0.49	3.21 ± 0.65	7.06 ± 1.32^++	0.004
RBC (/HPF)	33.4 ± 4.2	28.3 ± 5.2	13.4 ± 5.2	0.22
WBC (/HPF)	9.9 ± 1.4	11.1 ± 3.2	9.7 ± 2.9	0.91
NAG (U/gCr)	19.3 ± 2.53	21.1 ± 3.25	42.8 ± 11.1^+	0.010
Urinary IgG	1.49 ± 0.15	1.74 ± 0.29	2.43 ± 0.55	0.17
Urinary THP	0.39 ± 0.05	0.38 ± 0.05	0.36 ± 0.08	0.96
Urinary Tf	0.77 ± 0.08	0.74 ± 0.09	0.79 ± 0.12	0.95
Urinary albumin	3.07 ± 0.35	3.60 ± 0.52	5.02 ± 1.02	0.17
Urinary prealbumin	0.73 ± 0.08	0.67 ± 0.07	0.94 ± 0.30	0.52
Urinary α1MG	0.37 ± 0.03	0.48 ± 0.07	0.38 ± 0.10	0.26
Urinary LC	0.17 ± 0.20	0.20 ± 0.22	0.20 ± 0.06	0.37
Urinary β2MG	0.16 ± 0.18	0.18 ± 0.20	0.24 ± 0.06	0.52
SI	0.31 ± 0.04	0.29 ± 0.03	0.27 ± 0.04	0.92
Urinary podocyte (/HPF)	1.41 ± 0.24	1.41 ± 0.18	1.70 ± 0.45	0.14
Renal length (cm)	10.3 ± 0.12	10.4 ± 0.22	10.4 ± 0.48	0.28
RI	0.64 ± 0.01	0.64 ± 0.02	0.72 ± 0.02	0.046
Steroid/immunosuppressant	77%	66%	22%^+	0.0033
ARB/ACEI	52%	68%	89%	0.046
β-Blocker	11%	13%	11%	0.94
CCB	32%	63%	78%	0.001
MR blocker	8%	29%	11%	0.0140
Diuretics	36%	45%	56%	0.397

CR, complete remission; PR, partial remission; NS, nephrotic syndrome; WHP, water hammer pressure; NAG, N-acetyl-β-D-glucosaminidase; THP, Tamm–Horsfall protein; Tf, transferrin; MG, microglobulin; SI, selectivity index; RI, resistive index; CCB, calcium channel blocker; MR, mineral corticoid receptor. and vs. CR; ⁺ and ⁺⁺ vs. PR.