Research Article
Point-of-Care (POC) Urinary L-Type Fatty Acid-Binding Protein (u-LFABP) Use in Critically Ill, Very Preterm Neonates
Table 2
Perinatal factors and insults associated with u-LFABP profiles.
| | | u-LFABP | value | | Abnormal | Normal |
| | GA (weeks)1 | | 0–48 hours | 29 (28–31) | 30 (29–32) | 0.071 | | 72 hours+ | 29 (28–32) | 31 (30–32) | 0.017 | | 21 days+ | 30 (28–31) | 30 (28–32) | 0.837 |
| | Birth weight (g)2 | | 0–48 hours | 1220 (241.7) | 1449.25 (159.8) | 0.022 | | 72 hours+ | 1234.70 (203.3) | 1548.75 (259.9) | 0.013 | | 21 days+ | 1317.69 (259.2) | 1261.29 (188.0) | 0.619 |
| | PDA3 | | 0–48 hours | 10/11 (90.9) | 1/11 (9.1) | 0.149 | | 72 hours+ | 8/10 (80.0) | 2/10 (20.0) | 1.000 | | 21 days+ | 6/9 (66.7) | 3/9 (33.3) | 1.000 |
| | NEC3 | | 0–48 hours | 7/9 (77.8) | 2/9 (22.2) | 0.667 | | 72 hours+ | 7/8 (87.5) | 1/8 (12.5) | 1.000 | | 21 days+ | 4/6 (66.7) | 2/6 (33.3) | 1.000 |
| | Sepsis3 | | 0–48 hours | 15/18 (83.4) | 3/18 (16.7) | 0.291 | | 72 hours+ | 13/17 (76.5) | 4/17 (23.5) | 0.546 | | 21 days+ | 8/12 (66.7) | 4/12 (33.3) | 1.000 |
| | Vasopressor3 | | 0–48 hours | 4/4 (100.0) | 0/4 (0.0) | 0.277 | | 72 hours+ | 3/3 (100.0) | 0/3 (0.0) | 1.000 | | 21 days+ | 2/3 (66.7) | 1/3 (33.3) | 0.730 |
| | Nephrotoxic3 | | 0–48 hours | 18/23 (78.3) | 5/23 (21.7) | 0.022 | | 72 hours+ | 17/21 (81.0) | 4/21 (19.0) | 1.000 | | 21 days+ | 11/17 (64.7) | 6/17 (35.5) | 1.000 |
|
|
value <0.05; +Missing urine samples; 1Median (min–max) is presented, Mann–Whitney; 2Mean (SD) is presented, unpaired t-test; 3n (%) is presented, fisher’s exact test. GA: gestational age; PDA: patent ductus arteriosus; NEC: necrotizing enterocolitis. |
