Research Article
Renal Amyloidosis: Epidemiological, Clinical, and Laboratory Profile in Adults from One Nephrology Center
Table 1
Clinical and histological data of 310 patients with renal amyloidosis.
| | Parameter | Value | AA amyloidosis (n = 255) | Non-AA amyloidosis (n = 55) | value |
| | Male gender | 2.06 (209 M, 101 F) | 2.18 (175 M, 80 F) | 1.6 (34 M, 21 F) | NS | | Age (years) | 53.8 ± 15 | 52.8 | 58.5 | 0.012 | | Organ’s involvement, n (%) | | Digestive tract | 61/110 (55.4%) | 51 | 10 | NS | | Soft tissues | 87/227 (38.3%) | 63 | 24 | 0.004 | | Liver | 50/277 (18%) | 42 | 8 | NS | | Spleen | 18/264 (6.8%) | 13 | 5 | NS | | Lymphadenopathy | 21/168 (12.5%) | 15 | 6 | NS | | Hypoacusis | 29/122 (23.8%) | 26 | 3 | NS | | Goiter | 17/69 (24.6%) | 13 | 4 | NS | | Peripheral neuropathy | 3/14 (21.4%) | 0 | 3 | NS | | Clinical signs, n (%) | | Edema | 241/288 (83.7%) | 200 | 42 | NS | | Arterial hypotension | 123/310 (39.7%) | 101 | 22 | NS | | Orthostatic arterial hypotension | 50/310 (16.1%) | 37 | 13 | NS | | Arterial hypertension | 56/310 (18.1%) | 45 | 11 | NS | | Biology | | Proteinuria (g/24 h) | 6.4 (1–26) | 6.5 | 6 | NS | | Serum albumin (g/l) | 17 (4–42) | 17 | 21.3 | 0.0003 | | Nephrotic syndrome, n (%) | 84% | 212 | 39 | NS | | Creatinine (μmol/l) | 408 (37–3294) | 427.4 | 230 | 0.04 | | Normal renal function, n (%) | 99 (31.9%) | 79 | 20 | NS | | Chronic renal failure, n (%) | 94 (30.3%) | 75 | 19 | NS | | ESRD, n (%) | 117 (37.8%) (68 required HD) | 101 | 16 | NS |
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HD: hemodialysis; ESRD: end-stage renal disease; F: female; M: male; NS: not significant.
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