Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose

Figure 1

Causes and consequences of augmented renal clearance in critically ill patients. RBF: renal blood flow, GFR: glomerular filtration rate, TDM: therapeutic drug monitoring, PK/PD: pharmacokinetics/pharmacodynamics, SIRS: systemic inflammatory response syndrome. Modified from Sime FB [6].