Review Article

Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose

Table 1

Populations at risk of RHF. Adapted from Cook and Hatton-Kolpek [1].

PopulationPrevalence (%)Average CrCl value (ml/min)

Burned (burned surface ranged from 33 ± 21.3 percent of total body surface)65172.1
Sepsis39.5–56154–210
Subarachnoid hemorrhage100326
Febrile neutropenia16.4157.4
Trauma85.7166
Traumatic brain injury85150 (while not receiving CPP treatment)

CrCl: creatinine clearance; CPP: cerebral perfusion pressure.