Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose
Table 3
Efficacy of certain antibiotics based on pharmacodynamic properties. Modified from Roberts and Lipman [9].
Antibiotics
β-lactams
Aminoglycosides
Fluoroquinolones
Metronidazole
Carbapenem
Telithromycin
Aminoglycosides
Linezolid
Daptomycin
Azithromycin
Erythromycin
Quinupristin/dalfopristin
Tetracyclines
Clarithromycin
Glycopeptides
Lincosamides
Tigecycline
PD kill characteristics
Time-dependent
Concentration-dependent
Concentration-dependent with time-dependence
Optimal PD parameter
fT > MIC
Cmax/MIC
AUC 0–24/MIC
MIC: minimum inhibitory concentration; AUC: area under the curve, PD: pharmacodynamics, Cmax: maximum concentration, fT > MIC: free drug concentration above time.
