Exons 19 and 21 of Epidermal Growth Factor Receptor Are Highly Conserved in Squamous Cell Cancer of the Head and Neck

Figure 1

Mutational hotspots in EGFR gene clustering at ATP-binding pocket. The above sequences contain the 2 primary sites of interest for mutation analysis. The areas in red represent the regions where mutations most often occur. The mutation in exon 19 is most commonly a deletion mutation, while the mutation seen in exon 21 is a missense mutation (T → G substitution at nucleotide 2573 resulting in a L858R amino acid substitution).