Combined Application of 17-Estradiol and Progesterone Enhance Vascular Endothelial Growth Factor and Surfactant Protein Expression in Cultured Embryonic Lung Cells of Mice
Figure 4
Quantitative
analysis of VEGF gene expression in central lung fibroblasts treated for 48 hours
with increasing concentrations of both E2 and P and with ICI/RU 486. Values
were normalized against a housekeeping gene (HPRT) and expressed as % of
controls. Note that the application of receptor antagonists 1 hour prior to
hormone application (ICI/RU 486) antagonizes hormonal effects. control versus E2/P-8 M; control versus
E/P-6 M.
