Combined Application of 17-Estradiol and Progesterone Enhance Vascular Endothelial Growth Factor and Surfactant Protein Expression in Cultured Embryonic Lung Cells of Mice
Figure 8
Quantitative
analysis of SP-B and SP-C gene expression in alveolar cells type II treated for
48 hours with E2-8 M/P-8 M in combination or with dexamethasone-8 M.
Values were normalized against a housekeeping gene (HPRT) and expressed as % of
controls. Note that
combined hormonal treatment increased expression of both surfactant proteins to
a similar extent like dexamethasone. Further note that pretreatment with the receptor
antagonists ICI and RU 486 antagonized the hormonal effects. control versus E2/P-8 M; control versus D-8 M.
