Clinical and Epidemiological Features of Patients with Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Iran: Different Points of Children from Adults
Table 2
Drugs associated with Stevens-Johnson syndrome and toxic epidermal necrolysis in patients assisted at tertiary center in Iran.
Culprit medication
Pediatric ()
Adult ()
SJS ()
S/T ()
TEN ()
SJS ()
S/T ()
TEN ()
Antibiotics ()
12 (66.6)
1 (9)
0
17 (29.3)
5 (83.3)
2 (33.3)
Penicillin
2 (11.1)
0
0
3 (5.2)
3 (50)
0
Amoxicillin
4 (22.2)
0
0
1 (1.7)
1 (16.6)
0
Cefixime
0
0
0
3 (5.2)
0
2 (33.3)
Cefazolin
0
0
0
1 (1.7)
1 (16.6)
0
Cephalexin
0
0
0
1 (1.7)
0
0
Ceftriaxone
0
0
0
1 (1.7)
0
0
Levofloxacin (Tavanex)
0
0
0
1 (1.7)
0
0
Gentamicin
0
0
0
1 (1.7)
0
0
Ciprofloxacin
0
0
0
2 (3.4)
0
0
Coamoxiclav
2 (11.1)
0
0
0
0
0
Cotrimoxazole
3 (16.6)
1 (9)
0
1 (1.7)
0
0
Cloxacillin
0
0
0
1 (1.7)
0
0
Metronidazole
1 (5.5)
0
0
0
0
0
Nalidixic acid
0
0
0
1 (1.7)
0
0
Anticonvulsant ()
6 (33.3)
8 (72.7)
1 (50)
28 (48.3)
1 (16.6)
3 (50)
Carbamazepine
0
1 (9)
0
10 (17.2)
0
1 (16.7)
Phenytoin
0
0
0
5 (8.6)
0
1 (16.7)
Phenobarbital
2 (11.1)
6 (54.5)
1 (50)
1 (1.7)
0
0
Lamotrigine
2 (11.1)
1 (9)
0
9 (15.5)
0
0
Lamotrigine + Valproic acid
1 (5.5)
0
0
2 (3.4)
1 (16.6)
1 (16.7)
Topiramate
0
0
0
1 (1.7)
0
0
Levetiracetam
1 (5.5)
0
0
0
0
0
NSAID ()
0
0
0
3 (5.2)
0
1 (16.7)
Diclofenac
0
0
0
0
0
1 (16.7)
Gelofen
0
0
0
2 (3.4)
0
0
Piroxicam
0
0
0
1 (1.7)
0
0
Acyclovir
0
1 (9)
0
0
0
0
Methotrexate
0
0
0
1 (1.7)
0
0
5-fluorouracil
0
0
0
1 (1.7)
0
0
Allopurinol
0
0
0
1 (1.7)
0
0
Diltiazem
0
0
0
1 (1.7)
0
0
Carnisin
0
0
0
1 (1.7)
0
0
Undetermined
0
1 (9)
1 (50)
5 (8.6)
0
0
The data was presented by (%). SJS: Stevens-Johnson syndrome; TEN: toxic epidermal necrolysis; S/T: SJS/TEN overlap; NSAID: nonsteroidal anti-inflammatory drug.
