Clinical and Epidemiological Features of Patients with Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Iran: Different Points of Children from Adults
Table 3
Relationship between each of the studied predictive factors with the length of hospitalization in patients using multiple logistic regression model.
Predictors
Days of hospitalization
value
Adjusted OR
95% CI for OR
≤8 (, 55.4%)
>8 (, 44.6%)
Lower
Upper
%
%
Season
—
—
—
—
0.019
—
—
—
Spring
13
23.2
12
26.7
0.126
.221
.032
1.532
Summer
13
23.2
13
28.9
0.054
.151
.022
1.033
Autumn
22
39.3
9
20.0
0.002
.026
.003
.265
Winter
8
14.3
11
24.4
—
1
—
—
Culprit medication
—
—
—
—
0.020
—
—
—
Undetermined
2
3.6
5
11.1
0.091
.057
.002
1.572
Antibiotic
20
35.7
16
35.6
0.074
.149
.018
1.199
Antiepileptic
30
53.6
16
35.6
0.004
.009
.000
.209
Others
4
7.1
8
17.8
—
1
—
—
Reason for drug administration
—
—
—
—
0.017
—
—
—
Undetermined/no data
1
1.8
7
15.6
0.504
2.829
.134
59.921
Seizure
18
32.1
6
13.3
0.313
4.147
.261
65.910
Infection
21
37.5
17
37.8
0.732
1.497
.149
15.060
Psychiatry
9
16.1
11
24.4
0.003
91.667
4.749
1769.412
Others
7
12.5
4
8.9
—
1
—
—
Diagnosis
—
—
—
—
0.023
—
—
—
SJS
45
80.4
31
68.9
—
1
—
—
SJS/TEN
8
14.3
9
20.0
0.016
8.594
1.504
49.099
TEN
3
5.4
5
11.1
0.096
6.791
.712
64.748
SCORTEN
—
—
—
—
0.071
—
—
—
0
33
58.9
14
31.1
—
1
—
—
1
14
25.0
20
44.4
0.006
6.322
1.680
23.796
2
7
12.5
9
20.0
0.072
6.195
.849
45.226
3
2
3.6
1
2.2
0.828
.707
.031
15.967
4
0
0.0
1
2.2
>.999
—
—
—
Age group
—
—
—
—
—
—
—
Pediatric (≤18y)
23
41.1
8
17.8
0.014
.141
.029
.678
Adult (>18y)
33
58.9
37
82.2
—
1
—
—
Variables removed from first multiple logistic regression model regarding stepwise (backward LR) model reductions: sex, place of life, admission site, and time (days) to the onset of adverse effects, Mucosal involvement, Number of mucosal sites involved, sites of the lesion, temperature, and treatment. Omnibus test of model coefficients: ; -2 Log likelihood: 86.764; Cox & Snell R Square: .403; Nagelkerke R Square: .539; Hosmer and Lemeshow Test: .
