Thiomers: A Blessing to Evaluating Era of Pharmaceuticals

Table 2

Thiomers with their effect on mucoadhesion [11].

Thiomer	Increase in mucoadhesive strength
Chitosan iminothiolane	250 times
Polyacrylic acid-cysteine	100 times
Polyacrylic acid-homocysteine	Approx. 20 times [21]
Chitosan thioglycolic acid	10 times
Chitosan-thioethylamidine	9 times
Alginate cysteine	4 times
Poly methacrylic acid-cysteine	Improved cohesiveness and mucoadhesion [42, 43]
Sodium carboxy methyl cellulose-cysteine	Increased mucoadhesion
Gellan gum-2-iminothiolane	Increased mucoadhesion [44]
Carbopol 980	Increased mucoadhesion [45]
Hyaluronicacid-L-cysteine	Increased mucoadhesion [46]
Carboxymethyl hyaluronic acid	Improved cohesiveness and mucoadhesion [47]
Poly(ethylene glycol)-glutathione	Improved drug delivery [48, 49]
Sodium alginate	Improved drug delivery [27]