Research Article
Development of Duloxetine Hydrochloride Tablets for Delayed and Complete Release Using Eudragit L 100
Table 4
Evaluation results of coated formulations F5-F8.
| | Parameters | Formulations | | F5 | F6 | F7 | F8 |
| | Average weight (mg) | | | | | | Thickness (mm) | | | | | | Hardness kg/cm2 | | | | | | Acid uptake % | 100 | 85 | 20 | 3.6 | | Disintegration time (min) (0.1 N HCl) | 10-15 | 30-40 | 60-90 | Stable for 120 | | Disintegration time (min) (pH 6.8 phosphate buffer) | NA | NA | NA | 10 | | Dissolution (0.1 N HCl) | NA | NA | NA | 1.5% | | Dissolution (pH 6.8 phosphate buffer) | NA | NA | NA | 99% |
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NA: not applicable.
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