Development of Duloxetine Hydrochloride Tablets for Delayed and Complete Release Using Eudragit L 100

Table 6

Comparative dissolution profile of F8 with marketed product.

pH media	Time (min)	% cumulative drug release
		F8	Marketed product
PH 1.2 (2 H)	30	0	0.3
	60	0	0.3
	90	0.9	1.1
	120	1.5	1.6
pH 6.8 phosphate buffer (10 min)	122	58.4	51.5
	124	75.3	68.3
	126	84.2	81.4
	128	91.8	92.7
	130	99.8	98.5
	F2	88.4