Research Article
Controlled Release Bilayer Floating Effervescent and Noneffervescent Tablets Containing Levofloxacin and Famotidine
Table 1
Formulation of effervescent and noneffervescent floating controlled-release bilayer tablets.
| Drugs | Components of formulation (mg) | Effervescent bilayer tablets | Noneffervescent bilayer tablets | F1 | F2 | F3 | F4 | F5 |
| Levofloxacin Layer (LF) | Levofloxacin | 250 | 250 | 250 | 250 | 250 | Carbopol (934)+Methocel (K4) | 78 | | | | | Carbopol (934)+Methocel (K15) | | 78 | | 78 | 78 | Carbopol (934)+Methocel (K100) | | | 78 | | | Talc | 12.5 | 12.5 | 12.5 | 12.5 | 12.5 | Avecil (102) | 42 | 42 | 42 | 42 | 42 | Sodium bicarbonate | 78 | 78 | 78 | | | Magnesium stearate | 6 | 6 | 6 | 6 | 6 | Xanthan gum | | | | 78 | | Guar gum | | | | | 78 |
| Famotidine Layer (FM) | Famotidine | 20 | 20 | 20 | 20 | 20 | Carbopol (934)+Methocel (K4) | 60 | | | | | Carbopol (934)+Methocel (K15) | | 60 | | 60 | 60 | Carbopol (934)+Methocel (K100) | | | 60 | | | Talc | 3.5 | 3.5 | 3.5 | 3.5 | 3.5 | Avecil (102) | 18 | 18 | 18 | 18 | 18 | Sodium bicarbonate | 30 | 30 | 30 | | | Magnesium stearate | 2 | 2 | 2 | 2 | 2 | Xanthan gum | | | | 30 | | Guar gum | | | | | 30 |
|
|