Controlled Release Bilayer Floating Effervescent and Noneffervescent Tablets Containing Levofloxacin and Famotidine

Table 1

Formulation of effervescent and noneffervescent floating controlled-release bilayer tablets.

Drugs	Components of formulation (mg)	Effervescent bilayer tablets			Noneffervescent bilayer tablets
		F1	F2	F3	F4	F5
Levofloxacin; Layer (LF)	Levofloxacin	250	250	250	250	250
	Carbopol (934)+Methocel (K4)	78
	Carbopol (934)+Methocel (K15)		78		78	78
	Carbopol (934)+Methocel (K100)			78
	Talc	12.5	12.5	12.5	12.5	12.5
	Avecil (102)	42	42	42	42	42
	Sodium bicarbonate	78	78	78
	Magnesium stearate	6	6	6	6	6
	Xanthan gum				78
	Guar gum					78
Famotidine; Layer (FM)	Famotidine	20	20	20	20	20
	Carbopol (934)+Methocel (K4)	60
	Carbopol (934)+Methocel (K15)		60		60	60
	Carbopol (934)+Methocel (K100)			60
	Talc	3.5	3.5	3.5	3.5	3.5
	Avecil (102)	18	18	18	18	18
	Sodium bicarbonate	30	30	30
	Magnesium stearate	2	2	2	2	2
	Xanthan gum				30
	Guar gum					30