Research Article
Controlled Release Bilayer Floating Effervescent and Noneffervescent Tablets Containing Levofloxacin and Famotidine
Table 5
Release kinetics of levofloxacin and famotidine from bilayer floating tablets.
| Drugs | Code | Zero order | First order | Higuchi model | Korsmeyer-Peppas model | BFM | | | | | (min-1) | | Release mechanism |
| Levofloxacin layer (FL) | FL1 | 0.682 | 0.963 | 0.971 | 0.969 | 21.6 | 0.46 | Non-Fickian | HUM | FL2 | 0.677 | 0.928 | 0.978 | 0.981 | 22.6 | 0.45 | Non-Fickian | KPM | FL3 | 0.199 | 0.878 | 0.850 | 0.959 | 34.9 | 0.32 | Fickian | KPM | FL4 | 0.815 | 0.934 | 0.976 | 0.978 | 14.5 | 0.54 | Non-Fickian | KPM | FL5 | 1.000 | 0.974 | 0.968 | 0.971 | 14.9 | 0.57 | Non-Fickian | ZO |
| Famotidine layer (FM) | FM1 | 0.810 | 0.956 | 0.990 | 0.991 | 17.1 | 0.53 | Non-Fickian | KPM | FM2 | 0.681 | 0.972 | 0.977 | 0.979 | 22.9 | 0.46 | Non-Fickian | KPM | FM3 | 0.882 | 0.972 | 0.971 | 0.983 | 13.9 | 0.60 | Non-Fickian | KPM | FM4 | 0.970 | 0.910 | 0.791 | 0.981 | 1.31 | 1.29 | Non-Fickian | KPM | FM5 | 0.855 | 0.970 | 0.982 | 0.989 | 14.1 | 0.57 | Non-Fickian | KPM |
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Note: best fitting model: BFM; zero order: ZO; Higuchi model: HUM; Korsmeyer-Peppas model: KPM.
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