Controversies on Rituximab Therapy in Sjögren Syndrome-Associated Lymphoproliferation
Table 1
Patients with SS and lymphoma treated with rituximab.
Author, years
N. of pts
Type of lymphoma/bone marrow involvement
Ann Arbor Stage
Response on lymphoma
Other concomitant treatments for lymphoma
Shih, 2002
1
Parotid gland MALT-type/no
IE
Yes
No
Somer, 2003
1
Parotid gland MALT-type/no
IE
Yes
No
Voulgarelis, 2004*
4
(1) Salivary gland MALT-type/yes*
IV
Yes
(1) CHOP
(2) Nodal marginal zone/no*
IIE
Yes
(2) CHOP
(3) Pulmonary MALT-type/yes*
IV
Yes
(3) CHOP
(4) Salivary gland MALT-type/yes*
IV
Yes
(4) CHOP
Harner, 2004
1
Nodal marginal zone/Pulmonary MALT-type/no
IIE
Yes
No
Ramos-Casals, 2004
2
(1) Ovarian MALT-type/yes
IV
Yes
(1) CHOP
(2) Ocular MALT-type/yes
IV
Yes
(2) Local radiotherapy
Pijpe, 2005
1
Parotid gland MALT-type/no
IE
Yes
No
Gottenberg, 2005#
2
(1) Digestive tract MALT-type/no#
IE
Yes
(1) MP , HQ
(2) Salivary gland MALT-type/no#
IE
No
(2) No
Pijpe, 2005
7
(1) Parotid gland MALT-type/no
IE
No
(1) No
(2) Parotid gland MALT-type/no
IE
No
(2) PDN 15 mg/day
(3) Parotid gland MALT-type/no
IE
Yes
(3) No
(4) Parotid gland MALT-type/no
IE
Yes
(4) No
(5) Parotid gland MALT-type/no
IE
No
(5) PDN 7.5 mg/day, MTX
(6) Parotid gland MALT-type/no
IE
Yes
(6) PDN 5 mg/day, AZA
(7) Parotid gland MALT-type/no
IE
No
(7) No
Voulgarelis, 2006*
6
(1) Nodal marginal zone/no
II
Yes
(1) CHOP
(2) DLBCL/no
II
Yes
(2) CHOP
(3) Salivary gland MALT-type/yes*
IV
Yes
(3) CHOP
(4) Nodal marginal zone/no*
IIE
Yes
(4) CHOP
(5) Pulmonary MALT-type/yes*
IV
Yes
(5) CHOP
(6) Salivary gland MALT-type/yes*
IV
Yes
(6) CHOP
Seror, 2007#
5
(1) Salivary gland MALT-type/no#
IE
No
(1) No
(2) Nodal marginal zone/yes
IV
Yes
(2) No
(3) Gastric/pulmonary MALT-type/no
IV
Yes
(3) Mini-CHOP
(4) Gastric MALT-type/no#
IE
Yes
(4) HQ
(5) DLBCL/no
III
Yes
(5) CHOP
Quartuccio, 2008°
1
Parotid gland MALT-type/no°
IE
No
High-dose steroids
Carbone J, 2008
1
Low-grade marginal zone/yes
IV
Yes
CVP
Present report°
4
Parotid gland MALT-type/no°
IE
No
High-dose steroids
Lung MALT-type /no
IE
Yes
No
DLBCL + salivary MALT-type/no
IV
Yes
CNOP
Parotid gland MALT-type/yes
IV
Yes
Parotidectomy
Legend: pts, patients; MALT, mucosa-associated lymphoid tissue; CHOP, cyclophosphamide, doxorubicin, vincristine, prednisone; AZA, azathioprine; PDN, prednisone; MTX, methotrexate; MP, methylprednisolone; DLBCL, diffuse large B-cell lymphoma; HQ, hydroxychloroquine. There is some patients’ overlapping between the cases reported in Voulgarelis, 2004 and Voulgarelis, 2006. #There is some patients’ overlapping between the cases reported in Gottenberg, 2005 and Seror, 2007.
°There is some patients’ overlapping between the cases reported in Quartuccio, 2008 and present report.
