The association between AIRE rs760426 and the clinical parameters in the lupus patients.
Genotypes
Models
Alleles
Dominant
Recessive
GG ()
AG ()
AA ()
value
GG+AG ()
AA ()
value
OR (95% CI)
GG ()
AA+AG ()
value
OR (95% CI)
G
A
value
OR (95% CI)
Constitutional, (%)
12 (85.7)
12 (63.2)
37 (56.1)
0.115
24 (72.7)
37 (56.1)
0.108
2.1 (0.8-5.2)
12 (85.7)
49 (57.6)
0.073
4.4 (0.9-20.9)
34 (72.3)
88 (58.3)
0.083
1.9 (1-3.8)
MC, (%)
11 (78.6)
18 (94.7)
51 (77.3)
0.228
29 (87.9)
51 (77.3)
0.282
2.1 (0.6-7)
11 (78.6)
69 (81.2)
0.729
0.9 (0.2-3.4)
41 (87.2)
119 (78.8)
0.200
1.8 (0.7-4.7)
MSK, (%)
12 (85.7)
19 (100)
57 (86.4)
0.229
31 (93.9)
57 (86.4)
0.327
2.4 (0.5-12)
12 (85.7)
76 (89.4)
0.652
0.7 (0.1-3.7)
43 (91.5)
133 (88.1)
0.606
1.5 (0.5-4.5)
Serositis, (%)
9 (64.3)
10 (52.6)
30 (45.5)
0.421
19 (57.6)
30 (45.5)
0.255
1.6 (0.7-3.8)
9 (64.3)
40 (47.1)
0.232
2 (0.6-6.5)
27 (57.4)
71 (47.0)
0.212
1.5 (0.8-3)
Nephritis, (%)
11 (78.6)
14 (73.7)
47 (71.2)
0.849
25 (57.8)
47 (71.2)
0.632
1.3 (0.5-3.3)
11 (78.6)
61 (71.8)
0.752
1.4 (0.4-5.6)
35 (74.5)
109 (72.2)
0.759
1.1 (0.5-2.4)
Hematological, (%)
7 (50)
10 (52.6)
38 (57.6)
0.840
17 (51.5)
38 (57.6)
0.567
0.8 (0.3-1.8)
7 (50)
48 (56.5)
0.652
0.8 (0.2-2.4)
23 (48.9)
87 (57.6)
0.296
0.7 (0.4-1.4)
NPS, (%)
3 (21.4)
2 (10.5)
8 (12.1)
0.601
5 (15.2)
8 (12.1)
0.674
1.3 (0.4-4.3)
3 (21.4)
10 (11.8)
0.388
2 (0.5-8.6)
9 (19.1)
17 (11.3)
0.162
1.9 (0.8-4.5)
Cardiac, (%)
0 (0)
1 (5.3)
1 (1.5)
0.501
1 (3)
1 (1.5)
>0.999
2 (0.1-33.5)
0 (0)
2 (2.4)
>0.999
0 (0)
4 (2.6)
0.574
Pulmonary, (%)
0 (0)
1 (5.3)
1 (1.5)
0.501
1 (3)
1 (1.5)
>0.999
2 (0.1-33.5)
0 (0)
2 (2.4)
>0.999
2 (4.3)
2 (1.3)
0.239
3.3 (0.5-24.2)
Vasculitis, (%)
1 (7.1)
4 (21.1)
14 (21.2)
0.466
5 (15.2)
14 (21.2)
0.470
0.7 (0.2-2)
1 (7.1)
18 (21.2)
0.294
0.3 (0-2.3)
5 (10.6)
33 (21.9)
0.088
0.4 (0.2-1.2)
SDI ()
0.736
0.502
0.472
0.199
LSI ()
0.098
0.221
0.031
0.038
SLICC damage index ()
0.616
0.715
0.590
0.582
Comparisons were done using the Chi-square tests for the categorical data while the unpaired sample -test and the one-way ANOVA test were used to compare the quantitative data between two and multiple groups, respectively. : number. MC: mucocutaneous; MSK: musculoskeletal; NPS: neuropsychiatric; SDI: Lupus Severity of Disease Index; LSI: Lupus Severity Index; SLICC: Systemic Lupus International Collaborating Clinics; OR: odds ratio; CI: confidence interval.
