Molecular Markers in Cutaneous Squamous Cell Carcinoma

Table 1

High risk factors for NMSC tumor characteristics*.

Histologic differentiation
Poor differentiation
Spindle cell characteristics
Necrosis
High mitotic activity
Deep invasion
Depth of invasion
>2 mm
Clark level ^3IV
Perineural invasion
High risk anatomic sites
Nonglabrous Lip
Ear
Advanced T stage (T3 and T4)
Bony extension or involvement
Maxilla, mandible, orbit, temporal bone
Perineural invasion
Invasion of skull base
Invasion of axial or appendicular skeleton

*7th Edition of American Joint Commission on Cancer Staging Manual [18].