The Role of [¹⁸F]FDG-PET/CT in Predicting Malignant Transformation of Plexiform Neurofibromas in Neurofibromatosis-1

Table 2

Characteristics of the FDG-PET/CT studies.

Authors	Time between oral contrast administration and scan (minutes)	Mean of benign lesions	Mean of malignant lesions	Sensitivity (%)	Specificity (%)	Positive predictive value (%)	Negative predictive value (%)	Accuracy (%)	ROC analysis optimal cut-off
Ferner et al. [7]	55–60			n/a	n/a	n/a	n/a	n/a	n/a
Cardona et al. [8]	n/a	1.0	4.1	100	83	n/a	n/a	n/a	n/a
Bredella et al. [9]	45–60	1.5	8.5	95	72	71	95	82	n/a
Ferner et al. [10]	240			89	95	n/a	n/a	n/a	n/a
Karabatsou et al. [11]	60	2.6	10.4	n/a	n/a	n/a	n/a	n/a	n/a
Warbey et al. [12]	90 and 240	2 (1.9)	7 (8.1)	97	87	n/a	n/a	n/a	3.1
Benz et al. [13]	60			94	91	n/a	n/a	93	6.1
Moharir et al. [14]	45	n/a	n/a	100	86	50	100	n/a	n/a
Tsai et al. [15]	60			100/100/89	81/94/94	n/a	n/a	n/a	n/a
Derlin et al. [16]	60			100	74	28	100	77	4.1
Meany et al. [17]	60–90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Salamon et al. [18]	n/a	2.56	8.61	100	79.8	40	100	82	3.5
Chirindel et al. [19]	60 and 240	2 (2.3)	6.5 (8.3)	91	84 (81)	67 (63)	96	n/a	3.2

n/a: not available.
Value for delayed imaging.
Values as per cut-off of 3/4/5.