Predictive Factors of Positive Circumferential and Longitudinal Margins in Early T3 Colorectal Cancer Resection

Table 3

Univariate analysis for the clinicopathological parameters affecting longitudinal and circumferential margins (n = 50).

	Longitudinal resection margin		Circumferential resection margin
		OR (95% CI)		OR (95% CI)
Sex (male)	0.802	1.259 (0.208–7.638)	0.777	1.192 (0.353–4.018)
Age (years)	0.427	0.924 (0.761–1.123)	0.607	1.039 (0.897–1.204)
Tumor site (rectum)	0.005	15.60 (2.251–108.12)	0.007	10.850 (1.932–60.930)
Tumor size	0.376	1.513 (0.605–3.781)	0.702	1.128 (0.609–2.088)
Gross appearance (infiltrating)	0.021	9.0 (1.398–57.944)	0.010	6.444 (1.567–26.506)
Histopathological type (signet ring)	0.001	50.0 (4.626–540.444)	0.032	5.455 (1.159–25.662)
Tumor grade (Grade III)	0.030	11.923 (1.266–112.287)	0.019	4.464 (1.277–15.608)
Depth (pericolorectal tissue/Serosa)	0.030	11.923 (1.266–112.29)	<0.001	75.0 (11.291–498.196)
Advancing tumor front	0.098	0.152 (0.016–1.411)	0.998	—
Desmoplasia	0.174	3.50 (0.576–21.282)	0.184	2.250 (0.680–7.442)
Tumor budding	0.030	11.923 (1.266–112.29)	0.019	4.464 (1.277–15.608)
Lymph nodes involvement	0.018	15.0 (1.576–142.724)	0.001	10.267 (2.592–40.669)
Inflammation	0.511	1.826 (0.303–11.020)	0.097	2.880 (0.827–10.034)
Necrosis	0.143	3.867 (0.634–23.585)	0.033	3.810 (1.110–13.070)
Vascular invasion (positive)	0.009	12.667 (1.888–84.965)	0.013	7.0 (1.515–32.333)
Mitotic index	0.251	1.220 (0.869–1.713)	0.626	1.050 (0.863–1.277)
Apoptotic index	0.705	0.956 (0.759–1.205)	0.171	1.125 (0.950–1.333)
MVD (high)	0.042	1.401 (1.012–1.940)	0.001	1.731 (1.234–2.429)
Sinusoidal vascular pattern	0.003	31.667 (3.133–320.06)	0.025	5.075 (1.223–21.065)

OR: Odd`s ratio; CI: confidence interval; #: all variables with were included in the multivariate; : statistically significant at .