Survival Benefit of Intervention Treatment in Advanced Anaplastic Thyroid Cancer

Table 2

Unadjusted univariable Cox proportional hazard model of prognostic factors.

Variable	Hazard ratio (95% CI)	value
Age (years)
<65	Reference	0.022
≥65	1.6 (1.1–2.0)
Treatment
Intervention	Reference	0.001
Palliative	2.0 (1.3–3.0)
Staging
4a	Reference
4b	0.95 (0.7–1.7)	0.819
4c	1.35 (0.92–2.27)	0.221
Thyroid function test
Euthyroid	Reference
Hypothyroid	4.50 (1.19–13.57)	0.008
Hyperthyroid	3.75 (0.93–15.07)	0.063
White blood cell (cells/ml^3)
<10000	Reference
≥10000	2.05 (1.25–3.35)	0.004
Underlying disease
Absent	Reference
Present	1.19 (0.79–1.81)	0.403
Tumor size (cm)
<5	Reference
≥5	2.32 (0.84–6.38)	0.104
Extrathyroid extension
No	Reference
Yes	1.12 (0.75–1.69)	0.569
Cervical lymph node metastasis
No	Reference
Unilateral single	1.03 (0.64–1.65)	0.914
Unilateral multiple	0.76 (0.44–1.31)	0.328
Bilateral	1.41 (0.71–2.77)	0.323
Distance metastasis
No	Reference
Present (lung, bone, and liver)	1.33	0.183