The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases

Table 1

Virulence factor requirement during different ocular infectious diseases.

Virulence factor	Conjunctivitis	Keratitis	Endophthalmitis
	(reference)	(reference)	(reference)
Polysaccharide capsule	dispensable [7, 15, 64, 68, 112]	dispensable [7, 9]	necessary [105]
Pneumolysin (PLY)	Unknown	necessary [9, 32, 34]	necessary [25, 36, 37, 106]
Neuraminidase	necessary [7, 68]	necessary [7, 61]	unknown [108]
Zinc metalloproteinase C (ZmpC)	necessary [54, 55]	necessary [55]	unknown