Research Article
Evaluation of Adverse Drug Reaction Profile of Drugs Used as First-Line Antiretroviral Therapy
(a) Antiretroviral drugs and ADRs |
| | | Antiretroviral drugs | | | Zidovudine | Nevirapine | Stavudine | Efavirenz | Tenofovir |
| | Number of ADRs | 28 | 28 | 12 | 9 | 4 |
| | Percentage | 16.3% | 16.3% | 7.02% | 5.26% | 2.33% |
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(b) Distribution of adverse drug reactions by gender |
| | ADR | Males | Females | Total | p value |
| | Nausea | 12 | 16 | 28 | 0.408 |
| | Rash + Itching | 11 | 15 | 26 | 0.39 |
| | Fall in Hb/Anemia | 19 | 7 | 26 | 0.019 |
| | Gastrointestinal Intolerance | 10 | 7 | 17 | 0.613 |
| | Hepatotoxicity | 8 | 6 | 14 | 0.78 |
| | Neutropenia | 3 | 6 | 9 | 0.318 |
| | Thrombocytopenia | 3 | 5 | 8 | 0.486 |
| | Fatigue | 2 | 4 | 6 | 0.43 |
| | Lactic acidosis | 1 | 2 | 3 | 0.61 |
| | Dyslipidemia | 1 | 1 | 2 | 1.00 |
| | Peripheral neuropathy | 1 | 1 | 2 | 1.00 |
| | Headache+Insomnia | 1 | 1 | 2 | 1.00 |
| | Nephrotoxicity | 1 | 0 | 1 | 1.00 |
| | Pancreatitis | 1 | 0 | 1 | 1.00 |
| | Lipoatrophy | 0 | 1 | 1 | 0.48 |
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Chi-square test; =significant. |
