Interdisciplinary Perspectives on Infectious Diseases / 2019 / Article / Tab 4 / Clinical Study
Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South India Outcome Mortality valueYes No Age§ 47.3 (18.7) 30.9 (13.1) 0.016 Male (n = 96) 2 94 0.649 Days of fever§ 4.3 (2.2) 5.1 (2.2) 0.436 Rash (n = 59) 1 58 1.00 Myalgia (n = 96) 2 94 0.649 Arthralgia (n = 20) 1 19 0.419 Vomiting (n = 112) 3 109 1.00 Loose stools (n = 32) 0 32 0.584 Abdominal pain (n = 61) 2 59 0.638 Total leukocyte count (×109 /L)§ 10.4 (5) 5.9 (3.6) 0.015 Platelet count (×103 /μ L)§ 33 (36) 59 (65) 0.424 Creatinine (μ mol/L)§ 109 (61) 67.9 (29) 0.009 Total bilirubin (μ mol/L)§ 37.1 (22.2) 14.9 (20.5) 0.029 SGOT (serum glutamic oxaloacetic transaminase) (U/L)§ 4831 (7833) 304 (652) 0.0001 SGPT (serum glutamic pyruvic transaminase) (U/L)§ 1768 (2495) 164 (309) 0.0001 SOFAa score§ 7.25 (3.4) 3.16 (1.6) 0.0001 Major bleed (n = 108) 2 49 0.594 Late dengue (n = 39) 13 26 1.00 Severe dengue (n = 69) 2 67 1.00 Secondary dengue⋄ (n = 121) 4 117 0.573
a SOFA, sequential organ failure assessment;
§ mean (standard deviation);
value < 0.05 indicates a statistically significant association;
late dengue indicates presentation after 5 days of symptom onset;
⋄ secondary dengue has both IgG and IgM antibodies positive, while primary dengue has IgM and/or NS1 antigen positive.