Research Article

Frequency of rpoB, katG, and inhA Gene Polymorphisms Associated with Multidrug-Resistant Mycobacterium tuberculosis Complex Isolates among Ethiopian TB Patients: A Systematic Review

Table 1

Description of studies included in this systematic review.

1st author namePublication yearPublisher nameStudy areaStudy periodStudy designStudy populationSample size (n)TB patients’ casesSex ratioPatient age rangeCell culturing methodTotal positive cases (n)

Yigzaw et al. [22]2021DovePressAmhara region2018–2019Prospective cross-sectional studyPTB patient376New and relapse53.7% male and 46.3% female16–88LJ and MGIT 960 media176
Ayalew et al. [23]2021DovePressBishoftu, gondar, mekele and Hawass2016–2017NRTBLN patients91New and re-treated cases40.7% male and 59.3% female9–76NRNR
Tilahun et al. [24]2020PLOSAddis Ababa2017Cross-sectional studyPTB patient260NR56.3% male and 43.7% female>15LJ medium190
Welekidan et al. [25]2021ELSEVIERTigray region2018–2019Cross-sectional studyPTB patient300New63.4% male and 36.6% female>15LJ and MGIT 960 media227
Gashaw et al. [26]2021BMCOromia Special Zone and Dessie Town2015–2017Cross-sectional studyPTB and EPTB patient384New and pre-treated cases55.5% male and 45.5% female18–75LJ medium112
Welekidan et al. [27]2021FrontiersTigray region2018–2019Cross-sectional studyPTB patient300New63.4% male and 36.6% female>15LJ and MGIT 960 culture227
Total1711932

Note. PTB, pulmonary tuberculosis; EPTB, extra-pulmonary tuberculosis; TBLN, tuberculosis lymph node; NR, not reported.