Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19

Table 4

The expression level of healthy control, mild, and severe COVID-19 patients. Note: Values marked with an asterisk are not significantly different .

ID GENE	HC mean (N  = 5)	MILD mean (N  = 5)	SEVERE mean (N  = 5)	-value	Gene regulation in patient (up/down-regulated)
IFNAR1	6.963 ± 0.313	8.961 ± 0.282^∗	9.660 ± 0.305^∗	≤0.01	Up
IFI6	7.739 ± 0.228	10.569 ± 0.739^∗	10.461 ± 0.505^∗	≤0.01	Up
IRF7	6.886 ± 0.481	5.796 ± 0.102	4.985 ± 0.376	≤0.01	Down
IRF3	9.699 ± 0.762	8.074 ± 0.288^∗	7.713 ± 0.274^∗	≤0.01	Down
IFIT1	3.373 ± 0.247	5.743 ± 0.565^∗	5.214 ± 0.752^∗	≤0.01	Up
IFIT3	2.894 ± 0.286	4.387 ± 0.969^∗	4.699 ± 0.769^∗	≤0.01	Up
IFNA6	3.140 ± 0.230	5.424 ± 0.272^∗	5.731 ± 1.114^∗	≤0.01	Up
IFNB1	2.970 ± 1.208^∗	3.894 ± 0.461^∗	6.065 ± 0.244	≤0.01	Up
IFNG	11.731 ± 1.069^∗	9.729 ± 0.709^∗	8.273 ± 1.088	≤0.01	Down