Choosing Money over Drugs: The Neural Underpinnings of Difficult Choice in Chronic Cocaine Users
Table 1
Areas of significant BOLD signal differences between controls (Controls) and chronic cocaine users (CCUs) while viewing and submitting choices during single-commodity blocks of money now versus money later (MM) and cocaine now versus cocaine later (CC).
Conditions
H
Area
Coordinates
t-value
MM
View
Money now
Controls (23) > CCUs (24)
n/a
CCUs (24) > Controls (23)
R
Precuneus
6
−52
26
10
3.10
Money later
Controls (24) > CCUs (24)
L
IFG
−54
24
18
12
3.16
R
Inferior temporal
54
−44
−10
17
3.57
CCUs (24) > Controls (24)
n/a
Submit
Money now
Controls (23) > CCUs (24)
n/a
CCUs (24) > Controls (23)
n/a
Money later
Controls (23) > CCUs (24)
n/a
CCUs (24) > Controls (23)
n/a
CC
View
Cocaine now
Controls (20) > CCUs (23)
n/a
CCUs (23) > Controls (20)
n/a
Cocaine later
Controls (18) > CCUs (23)
n/a
CCUs (23) > Controls (18)
n/a
Submit
Cocaine now
Controls (20) > CCUs (23)
R
Temporal lobe
38
0
−22
10
3.37
L
Postcentral gyrus
−34
−28
50
11
3.03
CCUs (23) > Controls (20)
n/a
Cocaine later
Controls (18) > CCUs (23)
L
mPFC
6
48
30
10
3.30
CCUs (23) > Controls (18)
n/a
H: hemisphere. Listed areas correspond to location of the maximum voxel of activation with the activity cluster. Coordinates are listed in standard MNI space.