Structure-Induced Dynamics of Erythrocyte Aggregates by Microscale Simulation

Figure 1

Equilibrium configuration of four-cell rouleau obtained under no-flow condition with different intercellular strength and membrane deformability. The cells are placed at the center of a 15 μm by 15 μm square domain filled with blood plasma. The parameters used are (a) 𝐷_𝑒=1.0×10⁻² μJ/m², 𝑘_𝑏=1.0×10⁻¹³ Nm; (b) 𝐷_𝑒=1.0 μJ/m², 𝑘_𝑏=1.0×10⁻¹³ Nm; (c) 𝐷_𝑒=1.0×10⁻² μJ/m², 𝑘_𝑏=5.0×10⁻¹³ Nm; (d) 𝐷_𝑒=1.0 μJ/m², 𝑘_𝑏=5.0×10⁻¹³ Nm; (e) 𝐷_𝑒=1.0×10⁻² μJ/m², 𝑘_𝑏=3.0×10⁻¹² Nm; and (f) 𝐷_𝑒=1.0 μJ/m², 𝑘_𝑏=3.0×10⁻¹² Nm.

(a)

(b)

(c)

(d)

(e)

(f)