Research Article
A Dynamic Model of PI3K/AKT Pathways in Acute Myeloid Leukemia
Table 2
Parameter values and kinetic rates being used.
| Parameter | Description | Unit | Value | References |
| | PI3K level | | 0.01 – 0.1 | [21] | | Increase activation PIP3 by FOXO3ap | | 0.0083 | | | Constant rate of PIP3 dephosphorylation by PTEN | | 0.0006 – 0.21 | [21] | | PIP3 degradation | | 0.001 – 0.01 | [22] | | AKT production rate | | 0.036 – 0.108 | [21, 22] | | Constant rate of AKT phosphorylation | | 1 – 20 | [21] | | Constant rates of AKTp dephosphorylation by PP2A | | 0.36 – 13.5 | [21, 22] | | AKT degradation rate | | 0.063 – 0.08 | [21] | | AKTp degradation rate | | 0.0008 – 0.1 | [21, 22] | | FOXO3a production rate | | 0.002 – 0.5 | | | FOXO3a degradation rate by 14-3-3 protein | | 0.004 – 0.28 | | | Constant rate of FOXO3a phosphorylation | | 0 – 0.33 | | | Constant rate of FOXO3a dephosphorylation by PP2A | | 0.000297 – 2.92 | | | FOXO3ap degradation rate | | 0.033 – 0.125 | | | Michaelis constant of PIP3 dephosphorylation | | 0.01 – 1 | [18, 20] | | Michaelis constant of AKT phosphorylation | | 0.1 | [20] | | Michaelis constant of AKTp dephosphorylation | | 0.08 – 0.4 | [20, 22] | | Michaelis constant of FOXO3a phosphorylation | | 0.1 | | | Michaelis constant of FOXO3ap dephosphorylation | | 0.1 | |
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Parameters values are assumed to be the same as other transcription factors such as MDM2 in [ 18, 22]. |