Enhancing Malaria Control Strategy: Optimal Control and Cost-Effectiveness Analysis on the Impact of Vector Bias on the Efficacy of Mosquito Repellent and Hospitalization

<div>(a) Level set of <svg height="12.3054pt" id="M235" style="vertical-align:-3.29108pt" version="1.1" viewbox="-0.0498162 -9.01432 16.6699 12.3054" width="16.6699pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M852 669C820 657 792 643 768 628C705 667 627 687 547 687C310 687 154 548 154 412C154 332 212 282 296 282C434 282 515 426 523 557H503C474 402 410 312 298 312C241 312 195 352 195 408C195 535 341 657 546 657C613 657 683 644 738 609C640 538 574 431 486 271C374 71 314 16 189 16C118 16 69 60 69 95H71C78 84 93 83 101 83C129 83 144 106 144 131C144 160 121 179 93 179C60 179 34 151 34 108C34 42 100 -15 207 -15C364 -15 491 73 603 304C614 297 639 293 650 293C681 293 683 254 683 245C683 181 599 150 599 70C599 21 645 -12 692 -12C747 -12 804 30 868 103L851 119C789 52 741 18 706 18C685 18 674 29 674 52C674 92 750 157 750 226C750 257 727 287 696 310V312C812 315 876 394 876 473C876 525 849 577 793 612C812 627 832 639 859 650L852 669ZM814 486C814 417 765 345 686 337C669 348 649 354 626 354C673 451 708 533 766 588C799 561 814 525 814 486Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,12.272,3.132)"><path d="M387 400C387 425 348 451 303 451C247 451 176 414 132 376C69 322 24 228 24 148C24 43 74 -12 147 -12C211 -12 301 33 363 103L346 128C319 99 249 51 193 51C148 51 112 84 112 165C112 230 130 287 154 330C170 359 199 400 243 400C277 400 304 383 326 354C333 345 343 343 354 348C378 360 387 382 387 400Z"></path></g></svg> with respect to <svg height="9.14241pt" id="M236" style="vertical-align:-3.1815pt" version="1.1" viewbox="-0.0498162 -5.96091 12.001 9.14241" width="12.001pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M515 96L502 119C471 88 431 62 423 62C416 62 411 70 417 101C440 223 469 341 497 448H486L412 422L380 277C330 188 210 57 152 57C137 57 126 69 139 124L195 366C210 431 205 448 182 448C155 448 89 413 23 350L36 326C73 354 103 376 112 376C118 376 118 365 113 340L61 118C54 90 52 68 52 51C52 0 75 -12 98 -12S151 -3 181 17C242 58 305 119 362 193H364L345 104C323 3 339 -12 359 -12C390 -12 464 35 515 96Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.929,3.132)"><path d="M389 0V32C297 38 291 46 291 118V635C234 613 175 595 109 583V556L161 554C203 552 207 547 207 497V118C207 46 201 38 110 32V0H389Z"></path></g></svg> and <span class="nowrap"><svg height="9.14241pt" id="M237" style="vertical-align:-3.1815pt" version="1.1" viewbox="-0.0498162 -5.96091 12.001 9.14241" width="12.001pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M515 96L502 119C471 88 431 62 423 62C416 62 411 70 417 101C440 223 469 341 497 448H486L412 422L380 277C330 188 210 57 152 57C137 57 126 69 139 124L195 366C210 431 205 448 182 448C155 448 89 413 23 350L36 326C73 354 103 376 112 376C118 376 118 365 113 340L61 118C54 90 52 68 52 51C52 0 75 -12 98 -12S151 -3 181 17C242 58 305 119 362 193H364L345 104C323 3 339 -12 359 -12C390 -12 464 35 515 96Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.929,3.132)"><path d="M414 144C384 79 371 75 317 75H135L276 221C367 316 408 376 408 465C408 570 327 635 237 635C179 635 131 609 100 575L42 494L67 471C94 510 138 565 205 565C277 565 321 517 321 435C321 348 258 270 195 195C146 137 88 81 33 26V0H411C423 44 433 88 446 135L414 144Z"></path></g></svg>.</span> (b, c) Impact of vector bias on the effectiveness of <svg height="9.14241pt" id="M238" style="vertical-align:-3.1815pt" version="1.1" viewbox="-0.0498162 -5.96091 12.001 9.14241" width="12.001pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M515 96L502 119C471 88 431 62 423 62C416 62 411 70 417 101C440 223 469 341 497 448H486L412 422L380 277C330 188 210 57 152 57C137 57 126 69 139 124L195 366C210 431 205 448 182 448C155 448 89 413 23 350L36 326C73 354 103 376 112 376C118 376 118 365 113 340L61 118C54 90 52 68 52 51C52 0 75 -12 98 -12S151 -3 181 17C242 58 305 119 362 193H364L345 104C323 3 339 -12 359 -12C390 -12 464 35 515 96Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.929,3.132)"><path d="M389 0V32C297 38 291 46 291 118V635C234 613 175 595 109 583V556L161 554C203 552 207 547 207 497V118C207 46 201 38 110 32V0H389Z"></path></g></svg> and <svg height="9.14241pt" id="M239" style="vertical-align:-3.1815pt" version="1.1" viewbox="-0.0498162 -5.96091 12.001 9.14241" width="12.001pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M515 96L502 119C471 88 431 62 423 62C416 62 411 70 417 101C440 223 469 341 497 448H486L412 422L380 277C330 188 210 57 152 57C137 57 126 69 139 124L195 366C210 431 205 448 182 448C155 448 89 413 23 350L36 326C73 354 103 376 112 376C118 376 118 365 113 340L61 118C54 90 52 68 52 51C52 0 75 -12 98 -12S151 -3 181 17C242 58 305 119 362 193H364L345 104C323 3 339 -12 359 -12C390 -12 464 35 515 96Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.929,3.132)"><path d="M414 144C384 79 371 75 317 75H135L276 221C367 316 408 376 408 465C408 570 327 635 237 635C179 635 131 609 100 575L42 494L67 471C94 510 138 565 205 565C277 565 321 517 321 435C321 348 258 270 195 195C146 137 88 81 33 26V0H411C423 44 433 88 446 135L414 144Z"></path></g></svg> to reduce <span class="nowrap"><svg height="12.3054pt" id="M240" style="vertical-align:-3.29108pt" version="1.1" viewbox="-0.0498162 -9.01432 16.6699 12.3054" width="16.6699pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M852 669C820 657 792 643 768 628C705 667 627 687 547 687C310 687 154 548 154 412C154 332 212 282 296 282C434 282 515 426 523 557H503C474 402 410 312 298 312C241 312 195 352 195 408C195 535 341 657 546 657C613 657 683 644 738 609C640 538 574 431 486 271C374 71 314 16 189 16C118 16 69 60 69 95H71C78 84 93 83 101 83C129 83 144 106 144 131C144 160 121 179 93 179C60 179 34 151 34 108C34 42 100 -15 207 -15C364 -15 491 73 603 304C614 297 639 293 650 293C681 293 683 254 683 245C683 181 599 150 599 70C599 21 645 -12 692 -12C747 -12 804 30 868 103L851 119C789 52 741 18 706 18C685 18 674 29 674 52C674 92 750 157 750 226C750 257 727 287 696 310V312C812 315 876 394 876 473C876 525 849 577 793 612C812 627 832 639 859 650L852 669ZM814 486C814 417 765 345 686 337C669 348 649 354 626 354C673 451 708 533 766 588C799 561 814 525 814 486Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,12.272,3.132)"><path d="M387 400C387 425 348 451 303 451C247 451 176 414 132 376C69 322 24 228 24 148C24 43 74 -12 147 -12C211 -12 301 33 363 103L346 128C319 99 249 51 193 51C148 51 112 84 112 165C112 230 130 287 154 330C170 359 199 400 243 400C277 400 304 383 326 354C333 345 343 343 354 348C378 360 387 382 387 400Z"></path></g></svg>.</span></div>

Journal of Applied Mathematics

fig7

Figure 7

Figure 7: Enhancing Malaria Control Strategy: Optimal Control and Cost-Effectiveness Analysis on the Impact of Vector Bias on the Efficacy of Mosquito Repellent and Hospitalization 

Figure 7 | Enhancing Malaria Control Strategy: Optimal Control and Cost-Effectiveness Analysis on the Impact of Vector Bias on the Efficacy of Mosquito Repellent and Hospitalization 