Determination of Cefoperazone Sodium in Presence of Related Impurities by Linear Support Vector Regression and Partial Least Squares Chemometric Models

Table 3

Statistical comparison of the two proposed PLSR and linear SVR chemometric methods against the reported HPLC method for analysis of CEF in pharmaceutical formulations.

(a) Cefobid vial

Parameters	PLSR	Linear SVR	Reported HPLC method
Mean	102.77	100.30	102.85
SD	0.898	1.031	1.424
Variance	0.807	1.063	2.027
	6	6	6
Student’s -test (2.228)	0.907	0.006	—
-test (5.050)	2.513	1.907	—

(b) Cefoperazone vial

Parameters	PLSR	Linear SVR	Reported HPLC method
Mean	98.17	99.33	99.40
SD	1.078	0.993	1.317
Variance	1.161	0.985	1.736
	6	6	6
Student’s -test (2.228)	0.108	0.914	—
-test (5.050)	1.223	1.327	—

The values between parenthesis are corresponding to the theoretical values of and ().
Reference method is HPLC [15].