Development of Sensitive and Specific Analysis of Vildagliptin in Pharmaceutical Formulation by Gas Chromatography-Mass Spectrometry

Table 2

Conducted experimental runs for robustness and ruggedness studies.

Experiment number	Selected internal/external variables
	Analyst	Brand of MSTFA	Derivatization time (min)	Derivatization temperature (°C)
1		+		+
2	−	+	+	−
3	+	−	+	+
4	−	+	−	+
5	−	−	+	−
6	−	−	−	+
7	+	−	−	−
8	+	+	−	−
9	+	+	+	−
10	−	+	+	+
11	+	−	+	+
12	−	−	−	−

High level. Low level.