Transition Metal Complexes of Naproxen: Synthesis, Characterization, Forced Degradation Studies, and Analytical Method Verification

Table 1

Types of degradation reactions and conditions.

Degradation reaction	Typical conditions
Elevated temperature	Exposed to 105°C heat, up to 3 hours
Acid hydrolysis	Treated with 1 N HCl up to 24 hours
Base hydrolysis	Treated with 1 N NaOH up to 24 hours
Oxidation	Treated with 10% H2O2 solution up to 24 hours
Reduction	Treated with 10% Na bisulfite solution up to 24 hours
Water hydrolysis	Treated with water up to 24 hours