UPLC-Tandem Mass Spectrometry Method for Simultaneous Determination of Fluoxetine, Risperidone, and Its Active Metabolite 9-Hydroxyrisperidone in Plasma: Application to Pharmacokinetics Study in Rats

Table 5

Pharmacokinetic parameters of FLX, RIS, and 9-OH-RIS after oral concurrent administration of FLX and RIS to rats.

Parameters	FLX	RIS	9-OH-RIS
(ng/ml)	59.50 ± 6.66	234.52 ± 11.43	222.89 ± 15.86
(ngh/ml)	1861.56 ± 25.63	6434.70 ± 641.76	6360.01 ± 246.78
(ngh/ml)	2293.23 ± 196.09	6472.87 ± 652.21	6718.81 ± 184.35
(h)	0.243 ± 0.29	0.1205 ± 0.009	0.055 ± 0.005